紫檀芪对癌症的凋亡和非凋亡作用。
Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer.
机构信息
Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng-Kung University, Tainan 70101, Taiwan.
出版信息
Int J Mol Sci. 2018 Jan 18;19(1):287. doi: 10.3390/ijms19010287.
Cancer is a major cause of death. The outcomes of current therapeutic strategies against cancer often ironically lead to even increased mortality due to the subsequent drug resistance and to metastatic recurrence. Alternative medicines are thus urgently needed. Cumulative evidence has pointed out that pterostilbene (-3,5-dimethoxy-4-hydroxystilbene, PS) has excellent pharmacological benefits for the prevention and treatment for various types of cancer in their different stages of progression by evoking apoptotic or nonapoptotic anti-cancer activities. In this review article, we first update current knowledge regarding tumor progression toward accomplishment of metastasis. Subsequently, we review current literature regarding the anti-cancer activities of PS. Finally, we provide future perspectives to clinically utilize PS as novel cancer therapeutic remedies. We, therefore, conclude and propose that PS is one ideal alternative medicine to be administered in the diet as a nutritional supplement.
癌症是主要死因之一。当前针对癌症的治疗策略的结果往往具有讽刺意味，因为随后的耐药性和转移复发导致死亡率甚至更高。因此，迫切需要替代药物。累积的证据指出，白皮杉醇（-3,5-二甲氧基-4-羟基二苯乙烯，PS）通过诱发凋亡或非凋亡抗癌活性，在癌症的不同进展阶段对预防和治疗各种类型的癌症具有极好的药理益处。在这篇综述文章中，我们首先更新了有关肿瘤向转移完成进展的最新知识。随后，我们回顾了关于 PS 的抗癌活性的现有文献。最后，我们提供了将 PS 作为新型癌症治疗药物临床应用的未来展望。因此，我们得出结论并提出，PS 是一种理想的替代药物，可以作为营养补充剂在饮食中服用。
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