Pongcharoen Wipapan, Rukachaisirikul Vatcharin, Phongpaichit Souwalak, Sakayaroj Jariya
Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkla, Thailand.
Chem Pharm Bull (Tokyo). 2007 Sep;55(9):1404-5. doi: 10.1248/cpb.55.1404.
One new dihydrobenzofuran derivative, botryomaman (1), was isolated from the broth extract of the endophytic fungus Botryosphaeria mamane PSU-M76 along with six known compounds, 2,4-dimethoxy-6-pentylphenol, (R)-(-)-mellein, primin, cis-4-hydroxymellein, trans-4-hydroxymellein and 4,5-dihydroxy-2-hexenoic acid. The structures were assigned by spectroscopic methods. All compounds were tested for antibacterial activity against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus SK1. Primin showed the best activity against both strains with equal MIC values of 8 microg/ml.
从内生真菌芒果拟茎点霉PSU-M76的发酵液提取物中分离得到一种新的二氢苯并呋喃衍生物——葡萄孢菌素（1），以及六种已知化合物，即2,4-二甲氧基-6-戊基苯酚、（R）-（-）-蜜环菌素、致敏原、顺式-4-羟基蜜环菌素、反式-4-羟基蜜环菌素和4,5-二羟基-2-己烯酸。通过光谱方法确定了其结构。对所有化合物针对金黄色葡萄球菌ATCC 25923和耐甲氧西林金黄色葡萄球菌SK1进行了抗菌活性测试。致敏原对两种菌株均表现出最佳活性，其最低抑菌浓度（MIC）值均为8微克/毫升。
