Department of Reproductive Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi, 530021, China.
Sci Rep. 2018 Jan 18;8(1):1142. doi: 10.1038/s41598-017-17851-8.
The gut microbiome in humans is associated with geography, diet, lifestyles and so on, but its relationship with some isolated populations is not clear. We used the 16sRNA technique to sequence the fecal microbiome in the Chinese isolated Yao population and compared it with the major minority Zhuang and the major ethnic Han populations living in the same rural area. Information about diet frequency and health status and routine serum measurements were collected. The unweighted UniFrac principal coordinates analysis showed significant structural differences in fecal microbiota among the three ethnic groups. Statistically significant differences were observed in the community richness estimator (chaos) and the diversity estimator (Shannon) among the three groups. At the genus level, the fecal samples of the isolated Yao population presented the lowest relative abundance of the Megamonas genus, which was potentially related to the high frequency of bean consumption in the diet. Two enterotypes were identified in the overall fecal microbiota in the three populations. In the isolated Yao population, a higher Bacteroides abundance was observed, but the Prevotella abundance decreased with increased alcohol consumption.
人类的肠道微生物群与地理、饮食、生活方式等有关，但它与一些孤立的人群的关系尚不清楚。我们使用 16sRNA 技术对中国与世隔绝的瑶族人群的粪便微生物群进行了测序，并将其与生活在同一农村地区的主要少数民族壮族和主要民族汉族进行了比较。收集了关于饮食频率、健康状况和常规血清测量的信息。未加权 UniFrac 主坐标分析显示，三组人群的粪便微生物群结构存在显著差异。在群落丰富度估计值（混沌）和多样性估计值（香农）方面，三组之间存在统计学上的显著差异。在属水平上，与世隔绝的瑶族人群的粪便样本中 Megamonas 属的相对丰度最低，这可能与饮食中豆类的高食用频率有关。在三组人群的整体粪便微生物群中鉴定出了两种肠型。在与世隔绝的瑶族人群中，观察到更多的拟杆菌属，但随着酒精摄入的增加，普雷沃特氏菌属的丰度下降。
