Chen Jianbo, Li Meijia, Chen Lixue, Wang Yufang, Li Shanshan, Zhang Yuwei, Zhang Lei, Song Mingjie, Liu Chang, Hua Mei, Sun Yinshi
Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agriculture Sciences, Changchun, China.
J Ginseng Res. 2018 Jan;42(1):27-34. doi: 10.1016/j.jgr.2016.12.008. Epub 2017 Jan 11.
The use of different methods for the processing of ginseng can result in alterations in its medicinal properties and efficacy. White ginseng (WG), frozen ginseng (FG), and red ginseng (RG) are produced using different methods. WG, FG, and RG possess different pharmacological properties.
WG, FG, and RG extracts and pure ginsenosides were administered to rats to study the pharmacokinetics and tissue distribution characteristics of the following ginsenosides-Rg1, Re, Rb1, and Rd. The concentrations of the ginsenosides in the plasma and tissues were determined using UPLC-MS/MS.
The rate and extent of absorption of Rg1, Re, Rb1, and Rd appeared to be affected by the different methods used in processing the ginseng samples. The areas under the plasma drug concentration-time curves (AUCs) of Rg1, Re, Rb1, and Rd were significantly higher than those of the pure ginsenosides. In addition, the AUCs of Rg1, Re, Rb1, and Rd were different for WG, FG, and RG. The amounts of Rg1, Re, Rd, and Rb1 were significantly ( < 0.05) higher in the tissues than those of the pure ginsenosides. The amounts of Re, Rb1, and Rd from the RG extract were significantly higher than those from the WG and FG extracts in the heart, lungs, and kidneys of the rats.
Our results show that the use of different methods to process ginseng might affect the pharmacokinetics and oral bioavailability of ginseng as well as the tissue concentrations of Rg1, Re, Rd, and Rb1.
采用不同方法加工人参会导致其药用特性和功效发生改变。白参（WG）、冻参（FG）和红参（RG）是用不同方法生产的。WG、FG和RG具有不同的药理特性。
将WG、FG和RG提取物以及纯人参皂苷给予大鼠，以研究以下人参皂苷（Rg1、Re、Rb1和Rd）的药代动力学和组织分布特征。采用超高效液相色谱-串联质谱法（UPLC-MS/MS）测定血浆和组织中人参皂苷的浓度。
Rg1、Re、Rb1和Rd的吸收速率和程度似乎受加工人参样品所用不同方法的影响。Rg1、Re、Rb1和Rd的血浆药物浓度-时间曲线下面积（AUC）显著高于纯人参皂苷。此外，WG、FG和RG的Rg1、Re、Rb1和Rd的AUC也不同。组织中Rg1、Re、Rd和Rb1的含量显著（P<0.05）高于纯人参皂苷。在大鼠的心脏、肺和肾脏中，RG提取物中的Re、Rb1和Rd含量显著高于WG和FG提取物。
我们的结果表明，采用不同方法加工人参可能会影响人参的药代动力学和口服生物利用度，以及Rg1、Re、Rd和Rb1的组织浓度。
