School of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo, Shandong Province, China.
PLoS One. 2013 Aug 21;8(8):e70090. doi: 10.1371/journal.pone.0070090. eCollection 2013.
Certain saponins are bioactive compounds with anticancer, antivirus and antioxidant activities. This paper discussed inhibitory effects of saponins from Xanthoceras Sorbifolia on tyrosinase, through the research of the rate of tyrosinase catalyzed L-DOPA oxidation. The inhibition rate of tyrosinase activity presented non-linear changes with the saponins concentration. The rate reached 52.0% when the saponins concentration was 0.96 mg/ml. Antioxidant activities of saponins from Xanthoceras Sorbifolia were evaluated by using hydroxyl and superoxide radical scavenging assays. The hydroxyl radical scavenging effects of the saponins were 15.5-68.7%, respectively at the concentration of 0.18-2.52 mg/ml. The superoxide radical scavenging activity reduced from 96.6% to 7.05% with the time increasing at the concentration of 1.44 mg/ml. All the above antioxidant evaluation indicated that saponins from Xanthoceras Sorbifolia exhibited good antioxidant activity in a concentration- dependent manner.
某些皂素是具有抗癌、抗病毒和抗氧化活性的生物活性化合物。本文通过研究酪氨酸酶催化 L-DOPA 氧化的速率，探讨了从文冠果中提取的皂素对酪氨酸酶的抑制作用。酪氨酸酶活性的抑制率随皂素浓度呈非线性变化，当皂素浓度为 0.96mg/ml 时，抑制率达到 52.0%。采用羟基自由基和超氧自由基清除试验评价了文冠果皂素的抗氧化活性。在 0.18-2.52mg/ml 的浓度下，文冠果皂素对羟基自由基的清除率分别为 15.5-68.7%。在 1.44mg/ml 的浓度下，随着时间的延长，超氧自由基清除活性从 96.6%降低到 7.05%。所有这些抗氧化评价表明，文冠果皂素具有良好的抗氧化活性，且呈现浓度依赖性。
