Moussa Magdy, Leila Mahmoud, Khalid Hagar, Lolah Mohamed
Ophthalmology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
MEDIC Eye Center, Tanta, Egypt.
J Ophthalmol. 2017;2017:6913980. doi: 10.1155/2017/6913980. Epub 2017 Dec 4.
To evaluate the efficacy of SS-OCTA in the detection of silent CNV secondary to chronic CSCR compared to that of FFA and SS-OCT.
A retrospective observational case series reviewing the clinical data, FFA, SS-OCT, and SS-OCTA images of patients with chronic CSCR, and comparing the findings. SS-OCTA detects the CNV complex and delineates it from the surrounding pathological features of chronic CSCR by utilizing the blood flow detection algorithm, OCTARA, and the ultrahigh-definition B-scan images of the retinal microstructure generated by swept-source technology. The bivariate correlation procedure was used for the calculation of the correlation matrix of the variables tested.
The study included 60 eyes of 40 patients. Mean age was 47.6 years. Mean disease duration was 14.5 months. SS-OCTA detected type 1 CNV in 5 eyes (8.3%). In all 5 eyes, FFA and SS-OCT were inconclusive for CNV. The presence of foveal thinning, opaque material beneath irregular flat PED, and increased choroidal thickness in chronic CSCR constitutes a high-risk profile for progression to CNV development.
Silent type 1 CNV is an established complication of chronic CSCR. SS-OCTA is indispensable in excluding CNV especially in high-risk patients and whenever FFA and SS-OCT are inconclusive.
与荧光素眼底血管造影（FFA）和扫频光学相干断层扫描（SS-OCT）相比，评估扫频光学相干断层扫描血管造影（SS-OCTA）检测慢性中心性浆液性脉络膜视网膜病变（CSCR）继发的隐匿性脉络膜新生血管（CNV）的疗效。
一项回顾性观察病例系列研究，回顾慢性CSCR患者的临床数据、FFA、SS-OCT和SS-OCTA图像，并比较研究结果。SS-OCTA利用血流检测算法OCTARA以及扫频源技术生成的视网膜微观结构的超高分辨率B扫描图像，检测CNV复合体并将其与慢性CSCR的周围病理特征区分开来。采用双变量相关程序计算所测试变量的相关矩阵。
该研究纳入了40例患者的60只眼。平均年龄为47.6岁。平均病程为14.5个月。SS-OCTA在5只眼（8.3%）中检测到1型CNV。在所有5只眼中，FFA和SS-OCT对CNV的诊断均不明确。慢性CSCR中存在黄斑变薄、不规则扁平色素上皮脱离（PED）下方的不透明物质以及脉络膜厚度增加，构成了进展为CNV的高危特征。
隐匿性1型CNV是慢性CSCR的一种既定并发症。SS-OCTA在排除CNV方面不可或缺，尤其是在高危患者以及FFA和SS-OCT诊断不明确时。
