光学相干断层扫描血管造影术（OCTA）在神经学研究中的新兴应用。
Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research.
作者信息
Wang Liang, Murphy Olwen, Caldito Natalia Gonzalez, Calabresi Peter A, Saidha Shiv
机构信息
1Department of Biology, Johns Hopkins University, Krieger School of Arts and Sciences, Baltimore, MD USA.
2Division of Neuroimmunology and Neurological Infections, Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21287 USA.
出版信息
Eye Vis (Lond). 2018 May 12;5:11. doi: 10.1186/s40662-018-0104-3. eCollection 2018.
PURPOSE
To review the clinical and research value of optical coherence tomography angiography (OCTA) in the field of neurology.
METHODS
Current literature involving OCTA were reviewed through PubMed using the search terms "optical coherence tomography angiography", with "multiple sclerosis", "Alzheimer's disease", "optic neuropathy", or other closely-related terms.
RESULTS
OCTA has been applied in research to advance our understanding of the pathobiology of neurological disorders. OCTA-derived blood flow and vessel density measures are altered in multiple sclerosis (MS), Alzheimer's disease (AD), and various optic neuropathies (ON) in varying regions of the posterior segment vasculature of the eye. These emerging research findings support the occurrence of retinal vascular alterations across a host of neurological disorders and raise the possibility that vasculopathy can be clinically relevant since it contributes to the pathobiology of several neurological disorders.
CONCLUSION
OCTA may be beneficial for neurological research. Additional investigations using OCTA in neurological disorders will help to further validate its clinical and research utilities in terms of characterizing the role of vasculopathy in neurological disorders.
目的
探讨光学相干断层扫描血管造影（OCTA）在神经病学领域的临床及研究价值。
方法
通过PubMed检索当前涉及OCTA的文献，检索词为“光学相干断层扫描血管造影”，并结合“多发性硬化症”“阿尔茨海默病”“视神经病变”或其他密切相关术语。
结果
OCTA已应用于相关研究，以加深我们对神经疾病病理生物学的理解。眼部后段血管系统不同区域的血流和血管密度测量值在多发性硬化症（MS）、阿尔茨海默病（AD）及各种视神经病变（ON）中发生改变。这些新出现的研究结果支持在多种神经疾病中存在视网膜血管改变，并提出血管病变可能具有临床相关性，因为它参与了多种神经疾病的病理生物学过程。
结论
OCTA可能对神经疾病研究有益。在神经疾病中使用OCTA进行更多研究，将有助于进一步验证其在表征血管病变在神经疾病中的作用方面的临床及研究效用。
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