偕二烯丙基酯与邻醌甲基化物的（4 + 1）-加成反应。
Formal (4 + 1)-Addition of Allenoates to o-Quinone Methides.
机构信息
Institute of Organic Chemistry, Johannes Kepler University Linz , Altenbergerstrasse 69, 4040 Linz, Austria.
出版信息
Org Lett. 2018 Feb 2;20(3):768-771. doi: 10.1021/acs.orglett.7b03906. Epub 2018 Jan 19.
Abstract
The first (4 + 1)-annulation of o-quinone methides with α-branched allenoates as C1 synthons has been developed. This operationally simple protocol gives access to highly functionalized dihydrobenzofurans in an unprecedented fashion with excellent diastereoselectivities and high yields.
摘要
已开发出 o-醌甲川与作为 C1 合成子的α-支化丙二烯酸酯的首次（4+1）环加成反应。这种操作简单的方案以空前的方式提供了具有高非对映选择性和高产率的高度官能化二氢苯并呋喃。
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