Emerg Infect Dis. 2018 Feb;24(2):236-241. doi: 10.3201/eid2402.160378.
We conducted an investigation of Borrelia miyamotoi infections in humans and ticks in northeastern China. Of 984 patients reporting recent tick bites, 14 (1.4%) were found to be infected with B. miyamotoi by PCR and genomic sequencing. The 14 patients had nonspecific febrile manifestations, including fever, headache, anorexia, asthenia, and arthralgia. Rash, eschar, and regional lymphadenopathy were each observed in 1 patient. Four (28.6%) patients were hospitalized because of severe disease. B. miyamotoi was detected in 3.0% (19/627) of Ixodes persulcatus, 1 (2.8%) of 36 Haemaphysalis concinna, and none of 29 Dermacentor silvarum ticks. Phylogenetic analyses based on sequences of a nearly entire 16s rRNA gene, a partial flagellin gene, and the glycerophosphodiester phosphodiesterase gene revealed that B. miyamotoi identified in patients and ticks were clustered in the group of the Siberian type. These findings indicate that B. miyamotoi is endemic in northeastern China and its public health significance deserves further investigation.
我们对中国东北地区的人类和蜱虫中的伯氏疏螺旋体感染进行了调查。在报告近期蜱虫叮咬的 984 名患者中，14 名（1.4%）通过 PCR 和基因组测序发现感染了 B. miyamotoi。这 14 名患者表现出非特异性发热症状，包括发热、头痛、食欲不振、乏力和关节痛。皮疹、焦痂和局部淋巴结病各观察到 1 例患者。4 名（28.6%）因严重疾病住院。在 627 只 Ixodes persulcatus 蜱中，3.0%（19/627）检测到 B. miyamotoi，36 只 Haemaphysalis concinna 蜱中 1 只（2.8%）检测到，29 只 Dermacentor silvarum 蜱中均未检测到。基于近乎完整的 16s rRNA 基因、部分鞭毛蛋白基因和甘油磷酸二酯磷酸二酯酶基因序列的系统发育分析表明，患者和蜱虫中鉴定的 B. miyamotoi 聚集在西伯利亚型群体中。这些发现表明，B. miyamotoi 在中国东北地区流行，其公共卫生意义值得进一步研究。
