Johnstone E C, Owens D G, Crow T J, Frith C D, Alexandropolis K, Bydder G, Colter N
Division of Psychiatry, Clinical Research Centre, Harrow, Middlesex, UK.
J Neurol Neurosurg Psychiatry. 1989 Jun;52(6):736-41. doi: 10.1136/jnnp.52.6.736.
Temporal lobe structure has been assessed by magnetic resonance imaging in groups of patients with schizophrenia (n = 21) bipolar affective disorder (n = 20) and normal controls (n = 21). In the temporal lobe area a significant (p less than 0.05) diagnosis by side interaction was present, the area being less on the left than on the right side in patients with schizophrenia in contrast to findings in the two other groups. Lateral ventricular and temporal horn area did not distinguish the groups as a whole. However, there was a significant (p less than 0.05) relationship between lateral ventricular area and poor outcome, and in an analysis confined to males, patients with schizophrenia (n = 15) were found to have significantly (p less than 0.05) enlarged temporal horns.
已通过磁共振成像对精神分裂症患者组（n = 21）、双相情感障碍患者组（n = 20）和正常对照组（n = 21）的颞叶结构进行了评估。在颞叶区域，存在显著的（p < 0.05）诊断与侧别交互作用，与其他两组的结果相反，精神分裂症患者左侧的区域小于右侧。侧脑室和颞角区域总体上并未区分出这些组。然而，侧脑室区域与不良预后之间存在显著的（p < 0.05）关系，并且在仅限于男性的分析中，发现精神分裂症患者（n = 15）的颞角显著（p < 0.05）增大。
