Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Centre for Blood Research, Department of Pathology and Laboratory Medicine, University of British Columbia, 2350 Health Sciences Mall, Life Sciences Centre, Vancouver, BC V6T 1Z3, Canada.
Biomolecules. 2018 Jan 19;8(1):4. doi: 10.3390/biom8010004.
Antibiotic resistance is projected as one of the greatest threats to human health in the future and hence alternatives are being explored to combat resistance. Antimicrobial peptides (AMPs) have shown great promise, because use of AMPs leads bacteria to develop no or low resistance. In this review, we discuss the diversity, history and the various mechanisms of action of AMPs. Although many AMPs have reached clinical trials, to date not many have been approved by the US Food and Drug Administration (FDA) due to issues with toxicity, protease cleavage and short half-life. Some of the recent strategies developed to improve the activity and biocompatibility of AMPs, such as chemical modifications and the use of delivery systems, are also reviewed in this article.
抗生素耐药性被认为是未来人类健康的最大威胁之一，因此正在探索替代方法来对抗耐药性。抗菌肽 (AMPs) 显示出巨大的潜力，因为使用 AMPs 会导致细菌产生无或低耐药性。在这篇综述中，我们讨论了 AMPs 的多样性、历史和各种作用机制。尽管许多 AMPs 已经进入临床试验，但迄今为止，由于毒性、蛋白酶切割和半衰期短等问题，只有少数 AMPs 获得了美国食品和药物管理局 (FDA) 的批准。本文还回顾了为提高 AMPs 的活性和生物相容性而开发的一些最新策略，例如化学修饰和使用递药系统。
