疫苗抗性伪狂犬病病毒在中国引发水貂感染。
Vaccine resistant pseudorabies virus causes mink infection in China.
作者信息
Wang Gui-Sheng, Du Yijun, Wu Jia-Qiang, Tian Fu-Lin, Yu Xue-Jie, Wang Jin-Bao
机构信息
Shandong Provincial Center for Animal Disease Control and Prevention, Jinan, China.
School of Life Sciences, Shandong University, 27 Shanda Road South, Jinan, 250100, China.
出版信息
BMC Vet Res. 2018 Jan 19;14(1):20. doi: 10.1186/s12917-018-1334-2.
BACKGROUND
Pseudorabies, a highly contagious infectious disease of swine is caused by pseudorabies virus (PRV). PRV can cause fatal infection in other animal species.
RESULTS
We report a deadly outbreak of pseudorabies that killed 87.2% (3522/4028) minks in a farm in 2014 in Shandong Province, China. PRV was isolated by using Vero cell culture and detected in mink samples by PCR from minks died during the outbreak. Epidemiological analysis indicated that 5.8% of minks (33/566) were PCR positive to PRV in Shandong Province. Phylogenetic analysis indicated that the PRV strains isolated from minks in this study were in the same clade with the Chinese porcine PRV isolates, which are resistant to the PRV vaccine.
CONCLUSIONS
We demonstrated that pseudorabies virus caused an outbreak of minks in a farm in Shandong Province of China and the virus has a very high infection rate in minks in Shandong Province, which is a challenge for the fur industry in China.
背景
伪狂犬病是由伪狂犬病病毒（PRV）引起的猪的一种高度传染性疾病。PRV可在其他动物物种中引发致命感染。
结果
我们报告了2014年在中国山东省一个养殖场发生的一起致命伪狂犬病疫情，导致87.2%（3522/4028）的水貂死亡。通过使用Vero细胞培养分离出PRV，并在疫情期间死亡的水貂样本中通过PCR检测到该病毒。流行病学分析表明，山东省5.8%的水貂（33/566）对PRV的PCR检测呈阳性。系统发育分析表明，本研究中从水貂分离出的PRV毒株与中国猪PRV分离株属于同一进化枝，这些猪PRV分离株对PRV疫苗具有抗性。
结论
我们证明伪狂犬病病毒在中国山东省一个养殖场引发了水貂疫情，且该病毒在山东省水貂中的感染率非常高，这对中国的毛皮产业构成了挑战。
Zotero 插件