对CNC - 2在……中的潜在抗真菌特性的研究
An Investigation of the Potential Antifungal Properties of CNC-2 in .
作者信息
Zehrbach Angelina M D, Rogers Alexandra R, Tarr D Ellen K
机构信息
Master of Biomedical Sciences Program, College of Health Sciences, Midwestern University, Glendale, AZ 85308.
Department of Microbiology and Immunology, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ 85308.
出版信息
J Nematol. 2017 Dec;49(4):472-476.
responds to infections by upregulating specific antimicrobial peptides. The caenacin-2 () gene is consistently upregulated in by infection with the filamentous fungus , but there have been no direct studies of the CNC-2 peptide's in vivo or in vitro role in defending the nematode against this pathogen. We compared infection of wild-type and knockout nematode strains with four potential pathogens: , , , and . There was no significant difference in survival between strains for any of the pathogens or on the maintenance strain of . While we were unable to demonstrate definitively that CNC-2 is integral to fungal defenses in , we identified possible explanations for these results as well as future work that is needed to investigate CNC-2's potential as a new antifungal treatment.
通过上调特定抗菌肽来应对感染。丝状真菌感染秀丽隐杆线虫时，caenacin - 2（）基因持续上调，但尚未有关于CNC - 2肽在体内或体外抵御该病原体对线虫防御作用的直接研究。我们比较了野生型和缺失该基因的线虫菌株对四种潜在病原体（、、、）的感染情况。对于任何一种病原体或在秀丽隐杆线虫的维持菌株上，不同菌株之间的存活率没有显著差异。虽然我们无法明确证明CNC - 2对线虫抵御真菌至关重要，但我们为这些结果找到了可能的解释以及未来研究CNC - 2作为新型抗真菌治疗潜力所需开展的工作。
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