Emerg Infect Dis. 2013 Oct;19(10):1590-7. doi: 10.3201/eid1910.130427.
In the past decade, state-specific increases in the number of reported cases of coccidioidomycosis have been observed in areas of California and Arizona where the disease is endemic. Although most coccidioidomycosis is asymptomatic or mild, infection can lead to severe pulmonary or disseminated disease requiring hospitalization and costly disease management. To determine the epidemiology of cases and toll of coccidioidomycosis-associated hospitalizations in California, we reviewed hospital discharge data for 2000-2011. During this period, there were 25,217 coccidioidomycosis-associated hospitalizations for 15,747 patients and >$2 billion US in total hospital charges. Annual initial hospitalization rates increased from 2.3 initial hospitalizations/100,000 population in 2000 to 5.0 initial hospitalizations/100,000 population in 2011. During this period, initial hospitalization rates were higher for men than women, African Americans and Hispanics than Whites, and older persons than younger persons. In California, the increasing health- and cost-related effects of coccidioidomycosis-associated hospitalizations are a major public health challenge.
在过去的十年中，在加利福尼亚州和亚利桑那州的疾病流行地区，报告的球孢子菌病病例数量呈地方性增加。虽然大多数球孢子菌病是无症状或轻度的，但感染可导致严重的肺部或播散性疾病，需要住院治疗和昂贵的疾病管理。为了确定加利福尼亚州病例的流行病学和球孢子菌病相关住院的代价，我们回顾了 2000 年至 2011 年的医院出院数据。在此期间，有 15747 名患者的 25217 例球孢子菌病相关住院治疗，总住院费用超过 20 亿美元。初始住院率从 2000 年的每 10 万人 2.3 次初始住院增加到 2011 年的每 10 万人 5.0 次。在此期间，男性的初始住院率高于女性，非裔美国人高于白人，西班牙裔高于白人，老年人高于年轻人。在加利福尼亚州，球孢子菌病相关住院治疗带来的日益严重的健康和成本相关影响是一个主要的公共卫生挑战。
