用于比率型追踪细胞内黏度的发光双金属铱(III)配合物。
A luminescent bimetallic iridium(iii) complex for ratiometric tracking intracellular viscosity.
机构信息
State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, No. 2 linggong Road, Ganjingzi, District, Dalian 116023, China.
出版信息
Chem Commun (Camb). 2018 Feb 1;54(11):1371-1374. doi: 10.1039/c7cc09723a.
PMID:29354829
Abstract
A luminescent bimetallic iridium probe C10 was developed through a long soft carbon chain linkage to achieve ratiometric detection of viscosity. C10 features high sensitivity and selectivity for viscosity. More importantly, C10 is living cell permeable and can be employed to distinguish cancer cells from normal cells and track viscosity changes during MCF-7 cell apoptosis.
摘要
开发了一种通过长软碳链连接的发光双金属铱探针 C10，以实现对粘度的比率检测。C10 对粘度具有高灵敏度和选择性。更重要的是，C10 可穿透活细胞，并可用于区分癌细胞和正常细胞，以及跟踪 MCF-7 细胞凋亡过程中粘度的变化。
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