1Departamento de Nutrição,Universidade Federal da Paraíba,João Pessoa 58051-900,Paraíba,Brazil.
2Departamento de Patologia,Universidade Federal de Minas Gerais,Belo Horizonte 31270-901,Minas Gerais,Brazil.
Br J Nutr. 2018 Jan;119(1):30-41. doi: 10.1017/S0007114517003282.
This study assessed the effects of diet supplementation with industrial processing by-products of acerola (Malpighia emarginata D.C.), cashew (Anacardium occidentale L.) and guava (Psidium guajava L.) fruit on the intestinal health and lipid metabolism of female Wistar rats with diet-induced dyslipidaemia. Female rats were randomly divided into five groups: healthy control, dyslipidaemic control and dyslipidaemic experimental receiving acerola, cashew or guava processing by-products. Fruit processing by-products were administered (400 mg/kg body weight) via orogastric administration for 28 consecutive days. Acerola, cashew and guava by-products caused body weight reduction (3·42, 3·08 and 5·20 %, respectively) in dyslipidaemic female rats. Dyslipidaemic female rats receiving fruit by-products, especially from acerola, presented decreased faecal pH, visceral fat, liver fat and serum lipid levels, as well as increased faecal moisture, faecal fat excretion, faecal Bifidobacterium spp. and Lactobacillus spp. counts and amounts of organic acids in faeces. Administration of the tested fruit processing by-products protected colon and liver from tissue damage (e.g. destruction of liver and colon cells and increased fat deposition in hepatocytes) induced by dyslipidaemic diet. Dietary fibres and phenolic compounds in tested fruit by-products may be associated with these positive effects. The industrial fruit processing by-products studied, mainly from acerola, exert functional properties that could enable their use to protect the harmful effects on intestinal health and lipid metabolism caused by dyslipidaemic diet.
本研究评估了用工业加工副产物（樱桃李、腰果和番石榴）喂养饮食诱导性血脂异常的雌性 Wistar 大鼠对其肠道健康和脂质代谢的影响。雌性大鼠随机分为五组：健康对照组、血脂异常对照组和血脂异常实验组，分别接受樱桃李、腰果和番石榴加工副产物喂养。连续 28 天通过口服给予水果加工副产物（400mg/kg 体重）。樱桃李、腰果和番石榴副产物分别使血脂异常的雌性大鼠体重减轻（分别为 3.42%、3.08%和 5.20%）。接受水果副产物喂养的血脂异常雌性大鼠的粪便 pH 值、内脏脂肪、肝脏脂肪和血清脂质水平降低，粪便水分、粪便脂肪排泄量、粪便双歧杆菌和乳酸杆菌计数以及粪便中有机酸含量增加。这些水果加工副产物可保护结肠和肝脏免受饮食引起的组织损伤（例如，破坏肝细胞和结肠细胞以及肝内脂肪沉积增加）。测试的水果加工副产物中的膳食纤维和酚类化合物可能与这些积极影响有关。研究中使用的工业水果加工副产物，主要来自樱桃李，具有功能性特性，可用于保护肠道健康和脂质代谢免受饮食引起的血脂异常的有害影响。
