Silva Bernadete de Lourdes de Araújo, Vasconcelos Margarida Angélica da Silva, Batista Kamila Sabino, Batista Fabiane Rabelo da Costa, Cavalcante Hassler Clementino, Toscano Lydiane de Lima Tavares, Silva Alexandre Sérgio, D'Oliveira Aline Barbosa, Alves Adriano Francisco, Aquino Jailane de Souza
Nutrition Department, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
Nutrition Department, Universidade Federal da Paraíba, João Pessoa 58051-900, Brazil.
Foods. 2024 Nov 25;13(23):3773. doi: 10.3390/foods13233773.
The aim of this study was to evaluate the potential effects of administering mangaba powder on liver function and somatic, oxidative and lipid metabolism parameters in rats fed a high-fat diet. Prepared mangaba powder has important amounts of phenolic compounds, vitamin C, dietary fiber and oligosaccharides. A total of 32 adult Wistar rats were initially randomized into two groups for the biological assay: normal-fat (NF, n = 16) and high-fat (HF, n = 16) diets for 21 days. These rats were subsequently subdivided into four groups: NF (n = 8), HF (n = 8), normal-fat diet with mangaba powder administration (NFMG, n = 8) and high-fat diet with mangaba powder administration (HFMG, n = 8). The treatment with mangaba powder (400 mg/kg) lasted an additional 28 days. Compared to the HF rats, the HFMG rats showed an 8% reduction in the body mass index. Treatment with mangaba reduced the serum cholesterol by 18%, as well as the hepatic deposition of triacylglycerides by 26% and cholesterol by 25%, in addition to increasing bile acid synthesis by 77% in this organ. Mangaba powder consumption attenuated the degree of hepatic steatosis, reduced lipid peroxidation and increased the serum and hepatic antioxidant capacity in HFMG rats. These results show that the consumption of mangaba powder had lipid-lowering, hepatoprotective and antioxidant effects, especially in HFMG rats, which may be associated with an additive and synergistic action between the bioactive compounds present in the product.
本研究的目的是评估给予曼加巴果粉对高脂饮食喂养大鼠的肝功能以及躯体、氧化和脂质代谢参数的潜在影响。制备的曼加巴果粉含有大量酚类化合物、维生素C、膳食纤维和低聚糖。总共32只成年Wistar大鼠最初被随机分为两组进行生物学试验：正常脂肪（NF，n = 16）和高脂（HF，n = 16）饮食，持续21天。随后，这些大鼠被细分为四组：NF（n = 8）、HF（n = 8）、给予曼加巴果粉的正常脂肪饮食组（NFMG，n = 8）和给予曼加巴果粉的高脂饮食组（HFMG，n = 8）。用曼加巴果粉（400 mg/kg）治疗持续额外的28天。与HF大鼠相比，HFMG大鼠的体重指数降低了8%。用曼加巴治疗使血清胆固醇降低了18%，同时肝脏中三酰甘油的沉积减少了26%，胆固醇减少了25%，此外该器官中胆汁酸的合成增加了77%。食用曼加巴果粉减轻了HFMG大鼠肝脏脂肪变性的程度，减少了脂质过氧化，并提高了血清和肝脏的抗氧化能力。这些结果表明，食用曼加巴果粉具有降脂、保肝和抗氧化作用，特别是在HFMG大鼠中，这可能与该产品中存在的生物活性化合物之间的相加和协同作用有关。
