Departamento de Nutrição, Universidade Federal da Paraíba, João Pessoa, 58051-900, Paraíba, Brazil.
Food Funct. 2018 Aug 15;9(8):4480-4492. doi: 10.1039/c8fo01044g.
This study assessed the effects of supplementation with honey from Mimosa quadrivalvis L. (malícia) (MH) produced by jandaíra stingless bees (Melipona subnitida D.) on the lipid metabolism, antioxidant status and some intestinal health parameters of rats with diet-induced dyslipidaemia. Rats were randomly divided into four groups: healthy control (HC), dyslipidaemic control (DC), healthy experimental (EHH) and dyslipidaemic experimental (EDH). Malícia honey (MH) was administered (1000 mL kg-1) via orogastric feeding for 35 days. Dyslipidaemic rats supplemented with MH showed lower food consumption, increased glucose tolerance and superoxide dismutase (SOD) activity, and decreased total cholesterol, LDL and AST blood levels. Counts of Bifidobacterium spp. and Lactobacillus spp. and excretion of organic acids in faeces increased in dyslipidaemic rats supplemented with MH. MH supplementation protected the colon and liver from tissue damage induced by the dyslipidaemic diet. These results show the beneficial effects of MH on the lipid metabolism, antioxidant status and intestinal health of rats with diet-induced dyslipidaemia.
本研究评估了由黄檀属四蕊木（malícia）（MH）蜜和雅达蜜蜂（Melipona subnitida D.）生产的蜂蜜补充剂对饮食诱导血脂异常大鼠的脂质代谢、抗氧化状态和一些肠道健康参数的影响。大鼠随机分为四组：健康对照组（HC）、血脂异常对照组（DC）、健康实验组（EHH）和血脂异常实验组（EDH）。Malícia 蜂蜜（MH）通过口服喂养（1000 mL kg-1）给药 35 天。补充 MH 的血脂异常大鼠表现出较低的食物摄入量、增加的葡萄糖耐量和超氧化物歧化酶（SOD）活性，以及降低的总胆固醇、LDL 和 AST 血液水平。MH 补充剂还增加了血脂异常大鼠肠道中双歧杆菌和乳酸菌的计数以及粪便中有机酸的排泄。MH 补充剂保护了结肠和肝脏免受饮食引起的组织损伤。这些结果表明 MH 对饮食诱导血脂异常大鼠的脂质代谢、抗氧化状态和肠道健康具有有益作用。
