Thomas S R, Clark L C, Ackerman J L, Pratt R G, Hoffmann R E, Busse L J, Kinsey R A, Samaratunga R C
J Comput Assist Tomogr. 1986 Jan-Feb;10(1):1-9. doi: 10.1097/00004728-198601000-00001.
Certain perfluorocarbon (PFC) compounds, commonly used as the oxygen transport components of "blood substitutes," may be breathed as neat liquids with survival because of their chemical inertness and their high solubility for oxygen and carbon dioxide. In addition, the paramagnetism of oxygen reduces the fluorine T1 value according to an inverse relationship allowing a potential method of monitoring PO2 gradients in vivo. This article presents the results of magnetic resonance (MR) imaging of the lungs of mice and rats following breathing of four PFC liquids (FC-43, FC-75, PFOB, APF-215). The images presented were obtained at two magnetic field strengths (0.66 and 0.14 T) under conditions of breathing either ambient air or pure oxygen. Spin-lattice relaxation times (T1) for the PFCs are measured both in vitro and in vivo (in the lungs) as a function of the state of oxygenation. A MR image signal strength enhancement of up to 90% is demonstrated in vivo under conditions of pure oxygen breathing.
某些全氟化碳（PFC）化合物常用作“血液替代品”的氧运输成分，由于其化学惰性以及对氧气和二氧化碳的高溶解度，它们可以作为纯液体被吸入并维持生命。此外，氧气的顺磁性根据反比关系降低了氟的T1值，从而提供了一种在体内监测PO2梯度的潜在方法。本文介绍了小鼠和大鼠吸入四种PFC液体（FC-43、FC-75、全氟溴辛烷、APF-215）后肺部的磁共振（MR）成像结果。所呈现的图像是在两种磁场强度（0.66和0.14 T）下，在呼吸环境空气或纯氧的条件下获得的。全氟化碳的自旋晶格弛豫时间（T1）在体外和体内（肺部）均作为氧合状态的函数进行测量。在纯氧呼吸条件下，体内的MR图像信号强度增强高达90%。
