Fishman J E, Joseph P M, Floyd T F, Mukherji B, Sloviter H A
Pendergrass Diagnostic Radiology Research Laboratory, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia 19104.
Magn Reson Imaging. 1987;5(4):279-85. doi: 10.1016/0730-725x(87)90005-1.
The fluorine nuclear magnetic resonance spin-lattice relaxation rate (1/T1) of the perfluorochemical blood substitute perfluorotripropylamine (FTPA) is very sensitive to oxygen tension. This presents the possibility of measuring blood oxygen tension by 19F MR imaging. We obtained oxygen-sensitive 19F NMR images of the circulatory system of rats infused with emulsified FTPA. Blood oxygenation was assessed under conditions of both air- and 100% O2-breathing. T1 relaxation times were derived from MR images using a partial saturation pulse sequence. The T1 times were compared with a phantom calibration curve to calculate average blood pO2 values in the lung, liver, and spleen. The results showed marked, organ-specific increases in blood oxygen tension when the rat breathed 100% O2 instead of air.
全氟化学血液代用品全氟三丙胺（FTPA）的氟核磁共振自旋晶格弛豫率（1/T1）对氧分压非常敏感。这使得通过19F磁共振成像测量血氧分压成为可能。我们获得了注入乳化FTPA的大鼠循环系统的氧敏感19F核磁共振图像。在空气呼吸和100%氧气呼吸条件下评估血液氧合情况。使用部分饱和脉冲序列从磁共振图像中得出T1弛豫时间。将T1时间与模型校准曲线进行比较，以计算肺、肝和脾中的平均血液pO2值。结果显示，当大鼠呼吸100%氧气而非空气时，血液氧分压出现明显的、器官特异性的升高。
