从越南沿海水域采集的海星中发现的不寻常的多羟基甾醇。

Unusual Polyhydroxylated Steroids from the Starfish , Collected off the Coastal Waters of Vietnam.

机构信息

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.

Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.

出版信息

Molecules. 2020 Mar 23;25(6):1440. doi: 10.3390/molecules25061440.

DOI:10.3390/molecules25061440

PMID:32209997

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7145304/

Abstract

Four new polyhydroxylated steroids - were isolated along with two previously known related steroids and from the methanolic extract of the starfish collected off the coastal waters of Vietnam. Structures of new compounds were substantially elucidated by one-dimensional (1D) and two-dimensional (2D) NMR spectroscopy and HRESIMS techniques. Heptaol and hexaol contain the common 5α-cholestane skeleton, while hexaol and heptaol have the rare among starfish steroid compounds 5β-cholestane skeleton. Compounds , , and do not show cytotoxic effects against normal JB6 Cl41 and cancer HT-29 and MDA-MB-231 cells, however they inhibit cell proliferation and colony formation of cancer HT-29 and MDA-MB-231 cells.

摘要

从越南沿海水域采集的海星的甲醇提取物中分离得到了四种新的多羟基甾醇 - ，以及两种先前已知的相关甾醇和。通过一维（1D）和二维（2D）NMR 光谱和 HRESIMS 技术，基本阐明了新化合物的结构。Heptaol 和 hexaol 含有常见的 5α-胆甾烷骨架，而 hexaol 和 heptaol 则具有海星甾体化合物中罕见的 5β-胆甾烷骨架。化合物、、和对正常 JB6 Cl41 和癌症 HT-29 和 MDA-MB-231 细胞没有细胞毒性作用，但它们抑制癌症 HT-29 和 MDA-MB-231 细胞的增殖和集落形成。