Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Institute for Studies in Public Health, IESC, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Arch Oral Biol. 2018 Apr;88:19-23. doi: 10.1016/j.archoralbio.2018.01.010. Epub 2018 Jan 19.
The identification of clinical patterns of tooth agenesis in individuals born with craniofacial deformities may be a useful tool for risk determination of these defects. We hypothesize that specific craniofacial deformities are associated with third molar agenesis.
The aim of this study was to identify if third molar agenesis could have a relation with other craniofacial structure alterations, such as cleft lip and palate, skeletal malocclusion, or specific growth patterns in humans.
Data were obtained from 550 individuals ascertained as part of studies aiming to identify genetic contributions to oral clefts. 831 dental records of patients aged over eight years seeking orthodontic treatment were also included. SN-GoGn angle were used to classify the growth pattern (hypo-divergent, normal and hyper-divergent), and the ANB angle was used to verify the skeletal malocclusion pattern (Class I, II and III). Panoramic radiographs were used to determine third molar agenesis.
A high frequency of third molar agenesis among individuals born with cleft lip with or without cleft palate (55%), as well as among their relatives (93.5%) was found. Third molar agenesis was not associated to skeletal malocclusion or growth pattern.
It appears that third molar agenesis is associated with the disturbances that lead to cleft lip and palate.
在颅面畸形患者中识别牙齿缺失的临床模式可能是确定这些缺陷风险的有用工具。我们假设特定的颅面畸形与第三磨牙缺失有关。
本研究旨在确定第三磨牙缺失是否与其他颅面结构改变有关，如唇腭裂、骨骼错颌畸形或人类的特定生长模式。
数据来自 550 名作为旨在确定口腔裂遗传贡献的研究的一部分确定的个体。还包括 831 名年龄在 8 岁以上寻求正畸治疗的患者的牙科记录。SN-GoGn 角用于分类生长模式（低角、正常和高角），而 ANB 角用于验证骨骼错颌畸形模式（I 类、II 类和 III 类）。全景片用于确定第三磨牙缺失。
发现在有或没有唇腭裂的唇腭裂患者（55%）及其亲属（93.5%）中，第三磨牙缺失的发生率较高。第三磨牙缺失与骨骼错颌畸形或生长模式无关。
第三磨牙缺失似乎与导致唇腭裂的紊乱有关。
