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屈光不正、血管解剖结构与青光眼性视野缺损之间的相互关系。

The Interrelationship between Refractive Error, Blood Vessel Anatomy, and Glaucomatous Visual Field Loss.

作者信息

Wang Mengyu, Jin Qingying, Wang Hui, Li Dian, Baniasadi Neda, Elze Tobias

机构信息

Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA.

Jilin University, Changchun, China.

出版信息

Transl Vis Sci Technol. 2018 Jan 18;7(1):4. doi: 10.1167/tvst.7.1.4. eCollection 2018 Jan.

DOI:10.1167/tvst.7.1.4
PMID:29359110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5772833/
Abstract

PURPOSE

We quantified the interrelationship between retinal blood vessel (BV) anatomical variation, spherical equivalent (SE) of refractive error, and functional diagnostic parameters in glaucoma to identify optimal parameters for the improvement of optical coherence tomography (OCT) retinal nerve fiber layer thickness (RNFLT) norms.

METHODS

A trained observer marked the intersections of the main superior/inferior temporal arteries and veins with concentric circles around the optic nerve head (ONH) center on fundus images. The interrelationship of BV, SE, and visual field global parameters was analyzed by multivariate regression and model comparison.

RESULTS

A total of 445 eyes of 445 patients in a large glaucoma practice were selected. Of all investigated BV parameters, interartery angles (IAA) between superior and inferior arteries at a radius of 1.73 mm around the ONH center demonstrated the strongest relationship to SE (Bayesian information criterion difference to null model, 11.9). SE and BV parameters are unrelated to functional parameters, including mean deviation (MD), pattern standard deviation, and glaucoma hemifield test results.

CONCLUSIONS

BV locations outside the ONH are sufficiently stable over glaucoma severity to represent individual eye anatomy, and the IAA at 1.73 mm eccentricity is the optimal parameter to be considered for novel OCT RNFLT norms.

TRANSLATIONAL RELEVANCE

Among a large set of BV location parameters, considering IAA may improve RNFLT norms optimally and thereby increase the accuracy of clinical glaucoma diagnosis.

摘要

目的

我们量化了视网膜血管（BV）解剖变异、屈光不正的球镜等效度（SE）与青光眼功能诊断参数之间的相互关系，以确定改善光学相干断层扫描（OCT）视网膜神经纤维层厚度（RNFLT）标准的最佳参数。

方法

一名经过培训的观察者在眼底图像上标记主要颞上/颞下动脉和静脉与围绕视神经乳头（ONH）中心的同心圆的交点。通过多变量回归和模型比较分析BV、SE和视野全局参数之间的相互关系。

结果

在一个大型青光眼诊疗机构中，共选取了445例患者的445只眼睛。在所有研究的BV参数中，围绕ONH中心半径为1.73 mm处的上下动脉之间的动脉间角度（IAA）与SE的关系最为密切（与零模型的贝叶斯信息准则差异为11.9）。SE和BV参数与功能参数无关，包括平均偏差（MD）、模式标准差和青光眼半视野检测结果。

结论

在青光眼严重程度范围内，ONH外部的BV位置足够稳定，可代表个体眼部解剖结构，并且偏心度为1.73 mm处的IAA是新型OCT RNFLT标准应考虑的最佳参数。

转化相关性

在大量BV位置参数中，考虑IAA可能会最佳地改善RNFLT标准，从而提高临床青光眼诊断的准确性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/df081bfe89d7/i2164-2591-7-1-4-f08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/f5624ae2cb98/i2164-2591-7-1-4-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/1a1591c29052/i2164-2591-7-1-4-f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/88d247d888ab/i2164-2591-7-1-4-f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/a2d92afd5a21/i2164-2591-7-1-4-f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/50ff8ce10972/i2164-2591-7-1-4-f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/164aa15cc830/i2164-2591-7-1-4-f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/15b89bbd1979/i2164-2591-7-1-4-f07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/df081bfe89d7/i2164-2591-7-1-4-f08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/f5624ae2cb98/i2164-2591-7-1-4-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/1a1591c29052/i2164-2591-7-1-4-f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/88d247d888ab/i2164-2591-7-1-4-f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/a2d92afd5a21/i2164-2591-7-1-4-f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/50ff8ce10972/i2164-2591-7-1-4-f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/164aa15cc830/i2164-2591-7-1-4-f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/15b89bbd1979/i2164-2591-7-1-4-f07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a969/5772833/df081bfe89d7/i2164-2591-7-1-4-f08.jpg

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