Cheng Jingyi, Zhao Hongmei, Jiang Chunhui, Kong Xiangmei, Sun Xinghuai
Department of Ophthalmology and Visual Science, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China.
Key Laboratory of Myopia, Ministry of Health, Fudan University, Shanghai, China.
Front Med (Lausanne). 2021 Jul 8;8:705829. doi: 10.3389/fmed.2021.705829. eCollection 2021.
To investigate the changes in the retinal vessels (RVs) in different sectors in patients with primary open-angle glaucoma (POAG), and their possible correlations with retinal nerve fiber layer thickness (RNFLT) and visual-field defects in the temporal parapapillary region. The RV diameters, RNFLTs, and visual-field parameters were measured. The temporal parapapillary region was divided into the temporal (T, 315°-45°), temporal superior (TS, 45°-90°), and temporal inferior sectors (TI, 270°-315°). The changes in the RV diameters in each sector were determined, and their relationships with RNFLT, the mean deviation (MD), and visual field sensitivity (VFS) were examined. Fifty POAG patients (50 eyes) and 50 healthy subjects (50 eyes) were included. Compared with the healthy subjects, the POAG group had a significantly smaller accumulated parapapillary RV diameter ( < 0.001), which was positively correlated with the MD and RNFLT. When the different temporal sectors were examined, the accumulated RV diameters were significantly smaller in the POAG group than in the healthy controls in the TI and T sectors, but not in the TS sector. The accumulated diameters in the TI and T sectors were correlated with the corresponding RNFLTs (all < 0.05), but only the accumulated diameter in the TI sector was correlated with the VFS. In POAG, the changes in the RVs differed between different temporal sectors, with the most prominent changes occurring in the TI and T sectors.
为研究原发性开角型青光眼（POAG）患者不同象限视网膜血管（RVs）的变化，及其与颞侧视乳头旁区域视网膜神经纤维层厚度（RNFLT）和视野缺损的可能相关性。测量了RV直径、RNFLT和视野参数。将颞侧视乳头旁区域分为颞侧（T，315° - 45°）、颞上（TS，45° - 90°）和颞下象限（TI，270° - 315°）。确定每个象限RV直径的变化，并检查其与RNFLT、平均偏差（MD）和视野敏感度（VFS）的关系。纳入50例POAG患者（50只眼）和50名健康受试者（50只眼）。与健康受试者相比，POAG组视乳头旁RV累积直径显著更小（<0.001），且与MD和RNFLT呈正相关。检查不同颞侧象限时，POAG组TI和T象限的RV累积直径显著小于健康对照组，而TS象限则不然。TI和T象限的累积直径与相应的RNFLT相关（均<0.05），但仅TI象限的累积直径与VFS相关。在POAG中，不同颞侧象限的RV变化不同，TI和T象限变化最为显著。
