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微囊藻毒素在意大利撒丁岛两个富营养化地中海泻湖的贻贝类和水域中的存在。

Microcystins Presence in Mussels and Water of Two Productive Mediterranean's Lagoons (Sardinia, Italy).

机构信息

Department of Veterinary Medicine, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.

出版信息

Biomed Res Int. 2017;2017:3769245. doi: 10.1155/2017/3769245. Epub 2017 Nov 21.

DOI:10.1155/2017/3769245
PMID:29359150
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5735587/
Abstract

Microcystins (MCs) are hepatotoxins harmful for animal and human health. The most toxic type between them is MC-LR whose presence has been investigated in different reservoirs all around the world. In this work microcystins were monitored in spring and summer in water and mussels of two Sardinia lagoons: Cabras and Calich lagoons. A Solid Phase Extraction method was developed to clean and concentrate samples before the Enzyme Linked Immunosorbent Assay (ELISA) and the following Mass Spectrometry detection. MCs presence was detected using the screening ELISA test in both lagoons. MCs peak was revealed in July for water and mussels belonging to Cabras lagoon (0.75 ± 0.07 ng/L in water and 0.12 ± 0.04 ng/g ww in mussels). In water of Calich lagoon there was a constant trend in the concentration of MCs during the considered months, while there was a MCs peak in July (0.6 ± 0.5 ng/g ww) in mussels. The following LC-MS/MS analysis did not reveal MC-LR presence in all analyzed samples. These results can be useful to enrich knowledge on public health and consumer's safeguard.

摘要

微囊藻毒素（MCs）是对动物和人类健康有害的肝毒素。其中最具毒性的是 MC-LR，它的存在已在世界各地的不同水库中进行了调查。在这项工作中，对撒丁岛的两个泻湖（卡布拉斯泻湖和卡利奇泻湖）的水和贻贝中的微囊藻毒素进行了春夏季监测。开发了固相萃取法来对样品进行清洁和浓缩，然后进行酶联免疫吸附试验（ELISA）和随后的质谱检测。在两个泻湖中均使用筛选 ELISA 测试检测到了 MCs 的存在。在 7 月，卡布拉斯泻湖的水和贻贝中发现了 MCs 峰值（水中 0.75 ± 0.07ng/L，贻贝中 0.12 ± 0.04ng/g ww）。在卡利奇泻湖的水中，MCs 的浓度在考虑的几个月中呈持续趋势，而在 7 月贻贝中出现了 MCs 峰值（0.6 ± 0.5ng/g ww）。随后的 LC-MS/MS 分析并未在所有分析样本中发现 MC-LR 的存在。这些结果有助于丰富公共卫生和消费者保护方面的知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f616/5735587/86b6a5bf1e8d/BMRI2017-3769245.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f616/5735587/603fe0b971df/BMRI2017-3769245.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f616/5735587/19a08156dafb/BMRI2017-3769245.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f616/5735587/2948b14b1db0/BMRI2017-3769245.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f616/5735587/e84ee0339015/BMRI2017-3769245.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f616/5735587/86b6a5bf1e8d/BMRI2017-3769245.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f616/5735587/603fe0b971df/BMRI2017-3769245.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f616/5735587/19a08156dafb/BMRI2017-3769245.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f616/5735587/2948b14b1db0/BMRI2017-3769245.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f616/5735587/e84ee0339015/BMRI2017-3769245.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f616/5735587/86b6a5bf1e8d/BMRI2017-3769245.005.jpg

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