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本文引用的文献

1
Hepatotoxic seafood poisoning (HSP) due to microcystins: a threat from the ocean?微囊藻毒素导致的肝毒性海鲜中毒(HSP):海洋的威胁?
Mar Drugs. 2013 Aug 5;11(8):2751-68. doi: 10.3390/md11082751.
2
Climate change: a catalyst for global expansion of harmful cyanobacterial blooms.气候变化:有害蓝藻水华在全球范围内扩散的催化剂。
Environ Microbiol Rep. 2009 Feb;1(1):27-37. doi: 10.1111/j.1758-2229.2008.00004.x.
3
Cyanobacteria: potential candidates for drug discovery.蓝藻:药物发现的潜在候选者。
Antonie Van Leeuwenhoek. 2013 May;103(5):947-61. doi: 10.1007/s10482-013-9898-0. Epub 2013 Mar 27.
4
Marine cyanobacteria compounds with anticancer properties: a review on the implication of apoptosis.海洋蓝藻化合物的抗癌特性:细胞凋亡的意义综述。
Mar Drugs. 2012 Oct;10(10):2181-2207. doi: 10.3390/md10102181. Epub 2012 Sep 28.
5
Health risk assessment for cyanobacterial toxins in seafood.海产品中蓝藻毒素的健康风险评估。
Int J Environ Res Public Health. 2012 Mar;9(3):807-20. doi: 10.3390/ijerph9030807. Epub 2012 Mar 7.
6
Exploring marine cyanobacteria for lead compounds of pharmaceutical importance.探索具有药物重要性的铅化合物的海洋蓝细菌。
ScientificWorldJournal. 2012;2012:179782. doi: 10.1100/2012/179782. Epub 2012 Apr 1.
7
Cyanotoxins: bioaccumulation and effects on aquatic animals.蓝藻毒素:生物累积及其对水生动物的影响。
Mar Drugs. 2011 Dec;9(12):2729-2772. doi: 10.3390/md9122729. Epub 2011 Dec 16.
8
Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes.蓝藻中的天然产物生物合成:独特酶的宝库。
Beilstein J Org Chem. 2011;7:1622-35. doi: 10.3762/bjoc.7.191. Epub 2011 Dec 5.
9
Cyanobacterial blooms in stratified and destratified eutrophic reservoirs in semi-arid region of Brazil.巴西半干旱地区富营养化水库分层和去分层状态下的蓝藻水华
An Acad Bras Cienc. 2011 Dec;83(4):1327-38. doi: 10.1590/s0001-37652011000400019.
10
A review of pharmacological and toxicological potentials of marine cyanobacterial metabolites.海洋蓝藻代谢产物的药理和毒理学潜力综述。
J Appl Toxicol. 2012 Mar;32(3):153-85. doi: 10.1002/jat.1717. Epub 2011 Sep 9.

蓝藻和蓝藻毒素:从对水生生态系统和人类健康的影响到抗癌作用。

Cyanobacteria and cyanotoxins: from impacts on aquatic ecosystems and human health to anticarcinogenic effects.

机构信息

Universitary Center of Brasilia-UniCEUB-SEPN 707/907, Asa Norte, Brasília, CEP 70790-075, Brasília, Brazil.

出版信息

Toxins (Basel). 2013 Oct 23;5(10):1896-917. doi: 10.3390/toxins5101896.

DOI:10.3390/toxins5101896
PMID:24152991
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3813918/
Abstract

Cyanobacteria or blue-green algae are among the pioneer organisms of planet Earth. They developed an efficient photosynthetic capacity and played a significant role in the evolution of the early atmosphere. Essential for the development and evolution of species, they proliferate easily in aquatic environments, primarily due to human activities. Eutrophic environments are conducive to the appearance of cyanobacterial blooms that not only affect water quality, but also produce highly toxic metabolites. Poisoning and serious chronic effects in humans, such as cancer, have been described. On the other hand, many cyanobacterial genera have been studied for their toxins with anticancer potential in human cell lines, generating promising results for future research toward controlling human adenocarcinomas. This review presents the knowledge that has evolved on the topic of toxins produced by cyanobacteria, ranging from their negative impacts to their benefits.

摘要

蓝藻(蓝细菌)是地球的先驱生物之一。它们具有高效的光合作用能力,在早期大气的演化中发挥了重要作用。作为物种发展和进化的关键因素,它们在水生环境中容易大量繁殖,主要是由于人类活动。富营养化环境有利于蓝藻水华的出现,这不仅会影响水质,还会产生剧毒的代谢物。已经有描述表明人类会出现中毒和严重的慢性影响,如癌症。另一方面,许多蓝藻属已因其在人类细胞系中具有抗癌潜力的毒素而被研究,为未来控制人类腺癌的研究提供了有前景的结果。本篇综述介绍了关于蓝藻产生的毒素的相关知识,从它们的负面影响到它们的益处。