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Bunge 提取物通过 PI3K/Akt/NF-B 信号通路减轻重症急性胰腺炎相关性急性肺损伤

Involvement of the PI3K/Akt/NF-B Signaling Pathway in the Attenuation of Severe Acute Pancreatitis-Associated Acute Lung Injury by Bunge Extract.

机构信息

Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.

YueQing Affiliated Hospital of Wenzhou Medical University, YueQing People's Hospital, Yueqing, Zhejiang Province, China.

出版信息

Biomed Res Int. 2017;2017:9698410. doi: 10.1155/2017/9698410. Epub 2017 Dec 5.

DOI:10.1155/2017/9698410
PMID:29359164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5735615/
Abstract

Bunge possesses excellent anti-inflammatory properties and was used in the treatment of inflammatory diseases. The aim of the present study was to investigate the efficiency of Bunge extract (SSBE) on severe acute pancreatitis-associated (SAP-associated) acute lung injury (ALI) in rats and to explore the underlying mechanisms. Here, we used a sodium taurocholate-induced SAP rat model to determine the role of SSBE in ALI. During the course of pancreatitis, the expressions of phosphorylated phosphoinositide 3-kinases (PI3K)/protein kinase B (Akt) and nuclear factor-kappa B (NF-B) p65 in the lungs were upregulated. Meanwhile, a parallel increase in the levels of interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor- (TNF-) in the lungs was observed after the induction of SAP. Treatment with SSBE significantly reduced the expression of p-Akt and p-p65 in the lungs and attenuated the severity of SAP-associated ALI compared to the SAP group at 12 h and 24 h. In summary, this study showed that SSBE has beneficial effects on SAP-associated ALI, probably through the PI3-K/Akt signaling pathways by suppressing the NF-B activities.

摘要

Bunge 具有优异的抗炎特性，曾被用于治疗炎症性疾病。本研究旨在探讨 Bunge 提取物（SSBE）对大鼠重症急性胰腺炎相关（SAP 相关）急性肺损伤（ALI）的疗效，并探讨其潜在机制。在这里，我们使用牛磺胆酸钠诱导的 SAP 大鼠模型来确定 SSBE 在 ALI 中的作用。在胰腺炎过程中，肺组织中磷酸化磷脂酰肌醇 3-激酶（PI3K）/蛋白激酶 B（Akt）和核因子-κB（NF-κB）p65 的表达上调。同时，SAP 诱导后，肺组织中白细胞介素-1（IL-1）、白细胞介素-6（IL-6）和肿瘤坏死因子-（TNF-）的水平也呈平行增加。与 SAP 组相比，SSBE 治疗可显著降低肺组织中 p-Akt 和 p-p65 的表达，并减轻 SAP 相关 ALI 的严重程度，在 12 h 和 24 h 时更为明显。综上所述，本研究表明，SSBE 对 SAP 相关 ALI 具有有益作用，可能通过抑制 NF-κB 活性，通过 PI3-K/Akt 信号通路实现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d136/5735615/698be5aa2c44/BMRI2017-9698410.008.jpg
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