1Department of Nutrition and Dietetics, Faculty of Health Sciences,Kırıkkale University,71100 Kırıkkale,Turkey.
2Department of Medical Biochemistry, Faculty of Medical Sciences,Kırıkkale University,71100 Kırıkkale,Turkey.
Br J Nutr. 2018 Jan;119(2):153-162. doi: 10.1017/S0007114517003269.
Recently, it has been remarked that dietary fatty acids and fatty acid receptors might be involved in the aetiology of diabetes. Therefore, this study was conducted to determine the relationship between dietary fatty acid pattern, fatty food preferences and soluble CD36 (sCD36) and insulin resistance in type 2 diabetes mellitus (DM). The study was carried out with thirty-eight newly diagnosed type 2 DM patients and thirty-seven healthy volunteers, aged 30-65 years. In the study, socio-demographic characteristics, dietary fat type and fatty acid pattern of individuals were recorded. After anthropometric measurements were taken, blood CD36, glucose, TAG and insulin levels were analysed. The results showed that although the type of fatty acid intake did not differ between the groups (P>0·05), the consumption of olive oil in the type 2 DM group was lower than the control group (P0·05). Crucially, elevated sCD36 levels increased the type 2 DM risk (OR 1·21, P<0·05). In conclusion, sCD36 level may be a possible biomarker, independent from the dietary fatty acid pattern, for type 2 DM owing to its higher levels in these patients. Therefore, the new insights make CD36 attractive as a therapeutic target for diabetes.
最近，有人指出膳食脂肪酸和脂肪酸受体可能与糖尿病的病因有关。因此，本研究旨在确定 2 型糖尿病患者膳食脂肪酸模式、对高脂肪食物的偏好与可溶性 CD36（sCD36）和胰岛素抵抗之间的关系。该研究纳入了 38 名新诊断的 2 型糖尿病患者和 37 名年龄在 30-65 岁之间的健康志愿者。在研究中，记录了个体的社会人口统计学特征、膳食脂肪类型和脂肪酸模式。在进行人体测量后，分析了血液 CD36、葡萄糖、TAG 和胰岛素水平。结果表明，两组人群的脂肪酸摄入量没有差异（P＞0·05），但 2 型糖尿病组橄榄油的摄入量低于对照组（P＜0·05）。重要的是，升高的 sCD36 水平增加了 2 型糖尿病的风险（OR 1·21，P＜0·05）。总之，sCD36 水平可能是一种独立于膳食脂肪酸模式的 2 型糖尿病的潜在生物标志物，因为这些患者的 sCD36 水平更高。因此，这些新的认识使得 CD36 作为糖尿病的治疗靶点具有吸引力。
