Nigam Priyanka, Bhatt Suryaprakash, Misra Anoop, Chadha Davinder S, Vaidya Meera, Dasgupta Jharna, Pasha Qadar M A
1 National Diabetes, Obesity and Cholesterol Foundation , Safdarjung Development Area, New Delhi, India .
Diabetes Technol Ther. 2014 Apr;16(4):255-61. doi: 10.1089/dia.2013.0178.
We investigated the effects of dietary intervention with canola or olive oil in comparison with commonly used refined oil in Asian Indians with nonalcoholic fatty liver disease (NAFLD).
This was a 6-month intervention study including 93 males with NAFLD, matched for age and body mass index (BMI). Subjects were randomized into three groups to receive olive oil (n=30), canola oil (n=33), and commonly used soyabean/safflower oil (control; n=30) as cooking medium (not exceeding 20 g/day) along with counseling for therapeutic lifestyle changes. The BMI, fasting blood glucose (FBG) and insulin levels, lipids, homeostasis model of assessment for insulin resistance (HOMA-IR), HOMA denoting β-cell function (HOMA-βCF), and disposition index (DI) were measured at pre- and post-intervention. Data were analyzed with one-way analysis of variance (ANOVA) and Tukey's Honestly Significant Difference multiple comparison test procedures.
Olive oil intervention led to a significant decrease in weight and BMI (ANOVA, P=0.01) compared with the control oil group. In a comparison of olive and canola oil, a significant decrease in fasting insulin level, HOMA-IR, HOMA-βCF, and DI (P<0.001) was observed in the olive oil group. Pre- and post-intervention analysis revealed a significant increase in high-density lipoprotein level (P=0.004) in the olive oil group and a significant decrease in FBG (P=0.03) and triglyceride (P=0.02) levels in the canola oil group. The pre- and post-intervention difference in liver span was significant only in the olive (1.14 ± 2 cm; P<0.05) and canola (0.66 ± 0.33 cm; P<0.05) oil groups. In the olive and canola oil groups, post-intervention grading of fatty liver was reduced significantly (grade I, from 73.3% to 23.3% and from 60.5% to 20%, respectively [P<0.01]; grade II, from 20% to 10% and from 33.4% to 3.3%, respectively [P<0.01]; and grade III, from 6.7% to none and from 6.1% to none, respectively). In contrast, in the control oil group no significant change was observed.
Results suggest significant improvements in grading of fatty liver, liver span, measures of insulin resistance, and lipids with use of canola and olive oil compared with control oils in Asian Indians with NAFLD.
我们研究了用菜籽油或橄榄油进行饮食干预，与常用精炼油相比，对患有非酒精性脂肪性肝病（NAFLD）的亚洲印度男性的影响。
这是一项为期6个月的干预研究，纳入93名患有NAFLD的男性，根据年龄和体重指数（BMI）进行匹配。受试者被随机分为三组，分别接受橄榄油（n = 30）、菜籽油（n = 33）和常用的大豆/红花油（对照组；n = 30）作为烹饪介质（不超过20克/天），同时接受治疗性生活方式改变的咨询。在干预前后测量BMI、空腹血糖（FBG）和胰岛素水平、血脂、胰岛素抵抗评估的稳态模型（HOMA-IR）、表示β细胞功能的HOMA（HOMA-βCF）和处置指数（DI）。数据采用单因素方差分析（ANOVA）和Tukey's Honestly Significant Difference多重比较检验程序进行分析。
与对照组相比，橄榄油干预导致体重和BMI显著下降（ANOVA，P = 0.01）。在橄榄油和菜籽油的比较中，橄榄油组的空腹胰岛素水平、HOMA-IR、HOMA-βCF和DI显著下降（P < 0.001）。干预前后分析显示，橄榄油组的高密度脂蛋白水平显著升高（P = 0.004），菜籽油组的FBG（P = 0.03）和甘油三酯（P = 0.02）水平显著下降。肝右叶前后径的差异仅在橄榄油组（1.14±2厘米；P < 0.05）和菜籽油组（0.66±0.33厘米；P < 0.05）中显著。在橄榄油和菜籽油组中，干预后脂肪肝分级显著降低（I级，分别从73.3%降至23.3%和从60.5%降至20%[P < 0.01]；II级，分别从20%降至10%和从33.4%降至3.3%[P < 0.01]；III级，分别从6.7%降至无和从6.1%降至无）。相比之下，对照组未观察到显著变化。
结果表明，与对照组油相比，在患有NAFLD的亚洲印度人中，使用菜籽油和橄榄油可显著改善脂肪肝分级、肝右叶前后径、胰岛素抵抗指标和血脂。
