Chang Feng-Hang, Jette Alan M, Slavin Mary D, Baker Kristin, Ni Pengsheng, Keysor Julie J
Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, 250 Wu-Hsing Street, Taipei City, 11031, Taiwan.
MGH Institute of Health Professions, 36 1st Avenue, Charlestown Navy Yard, Boston, MA, 02129-4557, USA.
BMC Musculoskelet Disord. 2018 Jan 23;19(1):29. doi: 10.1186/s12891-018-1942-9.
The intent of this study was to examine and compare the ability to detect change of two patient reported outcome (PRO) instruments that use a computerized adaptive test (CAT) approach to measurement. The Patient Reported Outcomes Measurement Information System (PROMIS®) Physical Function scale is a generic PRO, while the Osteoarthritis Computerized Adaptive Test (OA-CAT) is an osteoarthritis-specific PRO.
This descriptive, longitudinal study was conducted in a community setting, involving individuals from the greater Boston area.
age > 50, self-reported doctor-diagnosed knee osteoarthritis (OA) and knee pain. The PROMIS® Physical Function CAT and OA-CAT Functional Difficulty scale were administered at baseline and at the conclusion of a 6-week exercise program. Effect sizes (ES) were calculated for both measures, and bootstrap methods were used to construct confidence intervals and to test for significant ES differences between the measures.
The OA-CAT Functional Difficulty scale achieved an ES of 0.62 (0.43, 0.87) compared to the PROMIS® Physical Function CAT ES of 0.42 (0.24, 0.63). ES estimates for the two CAT measures were not statistically different.
The condition-specific OA-CAT and generic PROMIS® Physical Function CAT both demonstrated the ability to detect change in function. While the OA-CAT scale showed larger effect size, no statistically significant difference was found in the effect size estimates for the generic and condition-specific CATs. Both CATs have potential for use in arthritis research.
This trial is registered with ClinicalTrials.gov on 6/21/11 (Identifier NCT01394874 ).
本研究旨在检验和比较两种采用计算机自适应测试（CAT）方法进行测量的患者报告结局（PRO）工具检测变化的能力。患者报告结局测量信息系统（PROMIS®）身体功能量表是一种通用的PRO工具，而骨关节炎计算机自适应测试（OA-CAT）是一种针对骨关节炎的PRO工具。
这项描述性纵向研究在社区环境中进行，涉及大波士顿地区的个体。
年龄>50岁，自我报告经医生诊断为膝关节骨关节炎（OA）且有膝关节疼痛。在基线时以及为期6周的运动计划结束时，分别使用PROMIS®身体功能CAT量表和OA-CAT功能困难量表进行测量。计算两种测量方法的效应量（ES），并采用自助法构建置信区间，以检验两种测量方法之间ES的显著差异。
与PROMIS®身体功能CAT量表的效应量0.42（0.24，0.63）相比，OA-CAT功能困难量表的效应量为0.62（0.43，0.87）。两种CAT测量方法的ES估计值在统计学上无差异。
针对特定疾病的OA-CAT量表和通用的PROMIS®身体功能CAT量表均显示出检测功能变化的能力。虽然OA-CAT量表显示出更大的效应量，但在通用型和针对特定疾病的CAT量表的效应量估计值中未发现统计学上的显著差异。两种CAT量表在关节炎研究中均有应用潜力。
本试验于2011年6月21日在ClinicalTrials.gov注册（标识符NCT01394874）。
