Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia.
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia.
Respirology. 2018 Jun;23(6):576-582. doi: 10.1111/resp.13239. Epub 2018 Jan 24.
The relationship between vitamin D and respiratory disease was examined by cross-sectional analysis of a large community-based sample.
Serum 25-hydroxyvitamin D (25OHD) and history of respiratory disease, symptoms (recorded by questionnaire) and spirometry were measured in 5011 adults aged 45-69 years. Adjustments were made for age, sex, season and smoking (Model A), plus body mass index (BMI) and physical activity level (Model B), plus history of chronic diseases (Model C).
Mean (SD) age was 58 (SD 6) years with 45% males, 10% current smokers and 12% taking vitamin D supplements. The prevalence of 25OHD level <50 nmol/L was 8.0%. In all the three models, 25OHD <50 nmol/L was significantly associated with asthma (Model C: odds ratio (OR): 1.32; 95% CI: 1.00, 1.73), bronchitis (1.54; 1.17, 2.01), wheeze (1.37; 1.10, 1.71) and chest tightness (1.42; 1.10, 1.83). Participants with vitamin D level > 100 nmol/L had higher forced vital capacity (FVC) in all the three models (1.17% higher, compared with the 50-100 nmol/L group in Model C).
Low levels of serum 25OHD were independently associated with asthma, bronchitis, wheeze and chest tightness after three levels of adjustment for potential confounders. Higher vitamin D levels were associated with higher levels of lung function.
通过对大型社区样本的横断面分析，研究了维生素 D 与呼吸道疾病之间的关系。
在 5011 名 45-69 岁的成年人中，测量了血清 25-羟维生素 D（25OHD）和呼吸道疾病史、症状（通过问卷记录）和肺功能。在模型 A 中，对年龄、性别、季节和吸烟状况进行了调整，在模型 B 中，对体重指数（BMI）和身体活动水平进行了调整，在模型 C 中，对慢性疾病史进行了调整。
平均（SD）年龄为 58（SD 6）岁，其中 45%为男性，10%为当前吸烟者，12%服用维生素 D 补充剂。25OHD 水平<50nmol/L 的患病率为 8.0%。在所有三个模型中，25OHD<50nmol/L 与哮喘（模型 C：比值比（OR）：1.32；95%置信区间：1.00，1.73）、支气管炎（1.54；1.17，2.01）、喘息（1.37；1.10，1.71）和胸闷（1.42；1.10，1.83）显著相关。在所有三个模型中，维生素 D 水平>100nmol/L 的参与者的用力肺活量（FVC）均较高（与模型 C 中 50-100nmol/L 组相比，高 1.17%）。
在对潜在混杂因素进行三级调整后，血清 25OHD 水平较低与哮喘、支气管炎、喘息和胸闷独立相关。较高的维生素 D 水平与较高的肺功能水平相关。
