Antunes-Rodrigues J, McCann S M, Samson W K
Endocrinology. 1986 Apr;118(4):1726-8. doi: 10.1210/endo-118-4-1726.
Atrial natriuretic factors (ANFs), produced in myocytes of mammalian atria, exert potent natriuretic and diuretic actions in the kidney as well as a variety of other actions coordinated to normalize extracellular fluid volume. Recently, ANF-like immunoreactivity has been detected in the hypothalamus of the rat, and central administration of ANF has been shown to block dehydration-induced water intake. We describe here the ability of 0.2 and 2.0 nmol atriopeptin III to inhibit saline intake when infused into the third ventricle of conscious, salt-depleted rats; an effect that was dose-related and long-lasting (24 h). These studies provide further evidence for a central nervous system action of ANF, which, together with its established renal and adrenal actions, might be an important feature of the coordinated physiological control of fluid volume.
心房利钠因子（ANFs）由哺乳动物心房的肌细胞产生，在肾脏中发挥强大的利钠和利尿作用，以及各种其他作用，以协调使细胞外液量正常化。最近，在大鼠下丘脑检测到了ANF样免疫反应性，并且已证明中枢给予ANF可阻断脱水诱导的饮水。我们在此描述当向清醒、缺盐的大鼠第三脑室注入0.2和2.0 nmol的心房肽III时，其抑制盐水摄入的能力；该效应呈剂量相关且持久（24小时）。这些研究为ANF的中枢神经系统作用提供了进一步的证据，这与其已确定的肾脏和肾上腺作用一起，可能是液体量协调生理控制的一个重要特征。
