Iitake K, Share L, Crofton J T, Brooks D P, Ouchi Y, Blaine E H
Endocrinology. 1986 Jul;119(1):438-40. doi: 10.1210/endo-119-1-438.
Atrial natriuretic factor (ANF, Arg 101-Tyr 126; 0.5 and 2.5 micrograms) administered into the lateral cerebral ventricle of conscious euhydrated and dehydrated rats resulted in a significant reduction in the plasma vasopressin concentration. The effect of ANF on vasopressin secretion was greater in the water-deprived animal. Central ANF was without effect on mean arterial blood pressure in both euhydrated and dehydrated rats. The data suggest that ANF occurring in the central nervous system may be important in the control of vasopressin secretion.
将心房钠尿肽（ANF，精氨酸101 - 酪氨酸126；0.5微克和2.5微克）注入清醒的水合正常和脱水大鼠的侧脑室后，血浆血管加压素浓度显著降低。在缺水动物中，ANF对血管加压素分泌的影响更大。中枢性ANF对水合正常和脱水大鼠的平均动脉血压均无影响。这些数据表明，中枢神经系统中存在的ANF可能在血管加压素分泌的控制中起重要作用。
