Institute of Environmental Science and Research Limited, Private Bag 92021, Auckland, 1142, New Zealand.
Institute of Environmental Science and Research Limited, Private Bag 92021, Auckland, 1142, New Zealand.
Forensic Sci Int Genet. 2018 May;34:11-24. doi: 10.1016/j.fsigen.2018.01.003. Epub 2018 Jan 8.
We report a large compilation of the internal validations of the probabilistic genotyping software STRmix™. Thirty one laboratories contributed data resulting in 2825 mixtures comprising three to six donors and a wide range of multiplex, equipment, mixture proportions and templates. Previously reported trends in the LR were confirmed including less discriminatory LRs occurring both for donors and non-donors at low template (for the donor in question) and at high contributor number. We were unable to isolate an effect of allelic sharing. Any apparent effect appears to be largely confounded with increased contributor number.
我们报告了一个庞大的概率基因分型软件 STRmix™ 的内部验证集合。31 个实验室提供了数据，其中包括 2825 个混合样本，每个样本包含三到六个供体，以及广泛的多重 PCR、设备、混合比例和模板。之前报道的 LR 趋势得到了证实，包括在低模板（对于所讨论的供体）和高供体数量时，供体和非供体的 LR 都具有较低的辨别力。我们无法分离等位基因共享的影响。任何明显的影响似乎主要与供体数量的增加混淆。
