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本文引用的文献

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Chemotherapy of experimental streptococcal endocarditis. I. Comparison of commonly recommended prophylactic regimens.实验性链球菌性心内膜炎的化疗。I. 常用推荐预防方案的比较。
J Clin Invest. 1973 Mar;52(3):592-8. doi: 10.1172/JCI107220.
2
Enoxacin compared with cefoperazone for the treatment of experimental Enterobacter aerogenes endocarditis.依诺沙星与头孢哌酮治疗实验性产气肠杆菌心内膜炎的比较。
Antimicrob Agents Chemother. 1985 May;27(5):708-11. doi: 10.1128/AAC.27.5.708.
3
Ciprofloxacin as therapy for experimental osteomyelitis caused by Pseudomonas aeruginosa.环丙沙星治疗铜绿假单胞菌引起的实验性骨髓炎。
J Infect Dis. 1985 Feb;151(2):291-4. doi: 10.1093/infdis/151.2.291.
4
The importance of pharmacodynamics in determining the dosing interval in therapy for experimental pseudomonas endocarditis in the rat.药效学在确定大鼠实验性假单胞菌性心内膜炎治疗给药间隔中的重要性。
J Infect Dis. 1986 Apr;153(4):707-14. doi: 10.1093/infdis/153.4.707.
5
Comparison of ciprofloxacin with azlocillin plus tobramycin in the therapy of experimental Pseudomonas aeruginosa endocarditis.环丙沙星与阿洛西林加妥布霉素治疗实验性铜绿假单胞菌心内膜炎的比较。
Antimicrob Agents Chemother. 1985 Sep;28(3):428-32. doi: 10.1128/AAC.28.3.428.
6
Antibiotic synergism in enterococcal endocarditis.肠球菌性心内膜炎中的抗生素协同作用。
J Lab Clin Med. 1976 Jul;88(1):132-41.

地氟沙星、依诺沙星和头孢哌酮治疗实验性产气肠杆菌心内膜炎的比较。

Comparison of difloxacin, enoxacin, and cefoperazone for treatment of experimental Enterobacter aerogenes endocarditis.

作者信息

Boscia J A, Kobasa W D, Kaye D

出版信息

Antimicrob Agents Chemother. 1987 Mar;31(3):458-60. doi: 10.1128/AAC.31.3.458.

DOI:10.1128/AAC.31.3.458
PMID:3472489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174752/
Abstract

This study compared difloxacin administered orally, enoxacin administered orally, and cefoperazone administered intramuscularly for the treatment of experimental Enterobacter aerogenes endocarditis. Difloxacin significantly reduced bacterial counts of vegetations, as compared with enoxacin and cefoperazone. Enoxacin and cefoperazone did not differ significantly. This study demonstrated that difloxacin was significantly more effective than enoxacin and cefoperazone for the treatment of E. aerogenes endocarditis in rabbits.

摘要

本研究比较了口服双氟沙星、口服依诺沙星和肌肉注射头孢哌酮治疗实验性产气肠杆菌心内膜炎的效果。与依诺沙星和头孢哌酮相比，双氟沙星能显著降低赘生物的细菌数量。依诺沙星和头孢哌酮之间无显著差异。本研究表明，在治疗兔产气肠杆菌心内膜炎方面，双氟沙星比依诺沙星和头孢哌酮显著更有效。