Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China.
Nanoscale. 2018 Feb 15;10(7):3130-3143. doi: 10.1039/c7nr06937e.
The vacancies in the semiconductor nanocrystals not only induce unique properties, but also provide spaces for engineering them with multifunctions by the introduction of other elements. Herein, the vacancy of CuSe nanoparticles was tuned by doping with magnetic ferric ions (Fe) at room temperature, and the position and intensity of the near-infrared localized surface plasmon resonance (LSPR) in the resultant nanostructure can be finely controlled by altering the feeding amount of Fe ions. The results of the density-functional theory (DFT) calculations show that both doping and replacement reactions are favourable. Owing to its tunable near-infrared absorption and magnetic property, the obtained hybrid nanostructure was demonstrated to be a novel nanotheranostic agent for effective deep-tissue photoacoustic imaging, magnetic resonance imaging, and photothermal therapy of cancer.
半导体纳米晶体中的空位不仅会产生独特的性质，而且还可以通过引入其他元素来为它们提供多功能的工程空间。在此，通过在室温下用磁性三价铁离子（Fe）掺杂来调节 CuSe 纳米粒子的空位，通过改变 Fe 离子的进料量可以精细控制所得纳米结构中近红外局域表面等离子体共振（LSPR）的位置和强度。密度泛函理论（DFT）计算的结果表明，掺杂和取代反应都是有利的。由于其可调谐的近红外吸收和磁性，所获得的杂化纳米结构被证明是一种用于有效深层光声成像、磁共振成像和癌症光热治疗的新型纳米治疗剂。
