Garteiser Philippe, Doblas Sabrina, Van Beers Bernard E
Laboratory of Imaging Biomarkers, Center of Research on Inflammation, UMR 1149 INSERM-University Paris Diderot, Paris, France.
Department of Radiology, Beaujon University Hospital Paris Nord, Clichy, France.
NMR Biomed. 2018 Oct;31(10):e3891. doi: 10.1002/nbm.3891. Epub 2018 Jan 25.
The viscoelastic properties of the liver and spleen can be assessed with magnetic resonance elastography (MRE). Several actuators, MRI acquisition sequences and reconstruction algorithms have been proposed for this purpose. Reproducible results are obtained, especially when the examination is performed in standard conditions with the patient fasting. Accurate staging of liver fibrosis can be obtained by measuring liver stiffness or elasticity with MRE. Moreover, emerging evidence shows that assessing the tissue viscous parameters with MRE is useful for characterizing liver inflammation, non-alcoholic steatohepatitis, hepatic congestion, portal hypertension, and hepatic tumors. Further advances such as multifrequency acquisitions and compression-sensitive MRE may provide novel quantitative markers of hepatic and splenic mechanical properties that may improve the diagnosis of hepatic and splenic diseases.
肝脏和脾脏的粘弹性特性可通过磁共振弹性成像（MRE）进行评估。为此已提出了几种激励器、MRI采集序列和重建算法。尤其是在患者禁食的标准条件下进行检查时，可获得可重复的结果。通过用MRE测量肝脏硬度或弹性，可实现肝纤维化的准确分期。此外，新出现的证据表明，用MRE评估组织粘性参数有助于表征肝脏炎症、非酒精性脂肪性肝炎、肝充血、门静脉高压和肝脏肿瘤。多频采集和压缩敏感MRE等进一步进展可能会提供肝脏和脾脏力学特性的新型定量标志物，从而改善肝脏和脾脏疾病的诊断。
