Department of Internal Medicine, Hospital Mutua Terrassa, University of Barcelona, Terrassa, Spain.
Department of Nephrology, Hospital del Mar, Barcelona, Spain.
J Clin Hypertens (Greenwich). 2018 Feb;20(2):266-272. doi: 10.1111/jch.13172. Epub 2018 Jan 25.
We aimed to evaluate the association of aortic and brachial short-term blood pressure variability (BPV) with the presence of target organ damage (TOD) in hypertensive patients. One-hundred seventy-eight patients, aged 57 ± 12 years, 33% women were studied. TOD was defined by the presence of left ventricular hypertrophy on echocardiogram, microalbuminuria, reduced glomerular filtration rate, or increased aortic pulse wave velocity. Aortic and brachial BPV was assessed by 24-hour ambulatory BP monitoring (Mobil-O-Graph). TOD was present in 92 patients (51.7%). Compared to those without evidence of TOD, they had increased night-to-day ratios of systolic and diastolic BP (both aortic and brachial) and heart rate. They also had significant increased systolic BPV, as measured by both aortic and brachial daytime and 24-hours standard deviations and coefficients of variation, as well as for average real variability. Circadian patterns and short-term variability measures were very similar for aortic and brachial BP. We conclude that BPV is increased in hypertensive-related TOD. Aortic BPV does not add relevant information in comparison to brachial BPV.
我们旨在评估主动脉和肱动脉短期血压变异性（BPV）与高血压患者靶器官损害（TOD）之间的关系。共研究了 178 名年龄 57±12 岁的患者，其中 33%为女性。TOD 定义为超声心动图左心室肥厚、微量白蛋白尿、肾小球滤过率降低或主动脉脉搏波速度增加。通过 24 小时动态血压监测（Mobil-O-Graph）评估主动脉和肱动脉 BPV。92 名患者（51.7%）存在 TOD。与无 TOD 证据的患者相比，他们的收缩压和舒张压（主动脉和肱动脉）及心率的昼夜比值增加。他们的日间和 24 小时收缩压标准差、变异系数以及平均真实变异性的主动脉和肱动脉日间和 24 小时标准偏差和变异系数也显著增加。主动脉和肱动脉 BP 的昼夜节律和短期变异性测量非常相似。我们的结论是，高血压相关 TOD 患者的 BPV 增加。与肱动脉 BPV 相比，主动脉 BPV 没有提供相关信息。
