Laboratory of Cellular and Molecular Immunology, GIGA-Research, Liege University, 4000 Liege, Belgium.
Laboratory of Cellular and Molecular Immunology, GIGA-Research, Liege University, 4000 Liege, Belgium.
Cell Immunol. 2018 Aug;330:91-96. doi: 10.1016/j.cellimm.2018.02.001. Epub 2018 Feb 8.
Lung macrophages have mostly been studied considering only their most accessible and well-defined representative, the alveolar macrophage (AM). In contrast, the identity and putative immune functions of their tissue counterpart, the interstitial macrophage (IM), have long remained much more elusive. Yet, recent evidence supports the notion that IMs perform important immune functions in the lung, notably in terms of innate immunoregulation. Here, we review current knowledge on the phenotype, ontogeny and function of IMs and propose strategies for the unambiguous identification and study of this important and dynamic lung innate immune cell population.
肺巨噬细胞主要是在考虑其最容易接近和最明确的代表肺泡巨噬细胞（AM）的情况下进行研究的。相比之下，其组织对应物间质巨噬细胞（IM）的特性和推测的免疫功能长期以来一直更加难以捉摸。然而，最近的证据支持这样一种观点，即 IM 在肺部中发挥重要的免疫功能，特别是在先天免疫调节方面。在这里，我们回顾了关于 IM 的表型、发生和功能的现有知识，并提出了明确识别和研究这一重要和动态的肺部先天免疫细胞群体的策略。
