Dabas Yubhisha, Xess Immaculata, Singh Gagandeep, Pandey Mragnayani, Meena Suneeta
Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110029, India.
J Fungi (Basel). 2017 Mar 23;3(2):17. doi: 10.3390/jof3020017.
Dermatophytes are associated with superficial infections in humans worldwide. The aim of the present study was to determine the species distribution and susceptibility patterns of clinical dermatophytes. Samples received for routine mycological processing from 124 suspected cases attending a dermatologic clinic in a tertiary care hospital were included in the study. On direct microscopy, 74.1% (92/124) were positive and 53.2% (66/124) grew on culture. The isolates were comprised of (56%) followed by (25.7%), (7.5%), (4.5%), (4.5%), and (1.5%). Conventional mycological identification was concordant with ITS sequencing except for . High minimum inhibitory concentration (MIC) values (geometric mean, >1 µg/mL) were observed for and to terbinafine and griseofulvin. This study highlights the shift in epidemiology from to . It also raises a concern of high MICs of terbinafine and griseofulvin among our isolates. Surveillance of antifungal susceptibility patterns can provide clinicians with local MIC data that can further aid in guiding better management in relapse cases of dermatomycosis.
皮肤癣菌与全球范围内人类的浅表感染有关。本研究的目的是确定临床皮肤癣菌的种类分布和药敏模式。本研究纳入了从一家三级护理医院皮肤科门诊就诊的124例疑似病例中接收的用于常规真菌学处理的样本。直接镜检时，74.1%（92/124）呈阳性，53.2%（66/124）培养生长。分离菌株包括[具体菌名1]（56%），其次是[具体菌名2]（25.7%）、[具体菌名3]（7.5%）、[具体菌名4]（4.5%）、[具体菌名5]（4.5%）和[具体菌名6]（1.5%）。除了[具体情况]外，传统真菌学鉴定与ITS测序结果一致。观察到[具体菌名1]和[具体菌名2]对特比萘芬和灰黄霉素的最低抑菌浓度（MIC）值较高（几何平均值，>1 µg/mL）。本研究突出了从[某种情况]到[另一种情况]的流行病学转变。它还引发了对我们分离菌株中特比萘芬和灰黄霉素高MIC值的担忧。对抗真菌药敏模式的监测可为临床医生提供当地MIC数据，这有助于进一步指导皮肤癣菌病复发病例的更好管理。
