Cunningham Suzanne M, Sweeney Joseph T, MacGregor John, Barton Bruce A, Rush John E
From the Department of Clinical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts (S.M.C., J.E.R.); MedVet Columbus, Worthington, Ohio (J.T.S.); New England Veterinary Cardiology, Portland, Maine (J.M.); and Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts (B.A.B.).
J Am Anim Hosp Assoc. 2018 Mar/Apr;54(2):95-102. doi: 10.5326/JAAHA-MS-6550. Epub 2018 Jan 26.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an important cause of sudden death in people and boxer dogs that has recently been described in English bulldogs. The objective of this retrospective study was to describe the clinical characteristics of English bulldogs with presumed ARVC. The medical records were searched for English bulldogs examined between 2001 and 2013 with a clinical diagnosis of ARVC. The average age of the 31 dogs identified was 9.2 ± 1.6 yr (range 7-13 yr). Males were overrepresented by a factor of 2.9 to 1. At initial presentation, 5 dogs had subclinical arrhythmia, 10 dogs had clinical signs attributable to arrhythmia, and 16 dogs had congestive heart failure. Eighteen dogs (58%) had ventricular tachycardia and five (16%) also had supraventricular arrhythmias. Four dogs experienced sudden death, 2 dogs died from congestive heart failure, 11 dogs were euthanized for cardiac causes, and 2 dogs died or were euthanized for noncardiac causes. Kaplan-Meier analysis showed a median survival time of 8.3 mo. This is the first study to describe the clinical characteristics of a population of English bulldogs with presumed ARVC. Further studies are needed to better characterize the clinical features of the disease in this breed.
致心律失常性右室心肌病（ARVC）是人和拳师犬猝死的重要原因，最近在英国斗牛犬中也有相关报道。这项回顾性研究的目的是描述疑似患有ARVC的英国斗牛犬的临床特征。检索了2001年至2013年间接受检查且临床诊断为ARVC的英国斗牛犬的病历。所确定的31只犬的平均年龄为9.2±1.6岁（范围7 - 13岁）。雄性犬的比例是雌性的2.9倍。初次就诊时，5只犬有亚临床心律失常，10只犬有可归因于心律失常的临床症状，16只犬有充血性心力衰竭。18只犬（58%）有室性心动过速，5只犬（16%）也有室上性心律失常。4只犬发生猝死，2只犬死于充血性心力衰竭，11只犬因心脏原因被安乐死，2只犬因非心脏原因死亡或被安乐死。Kaplan - Meier分析显示中位生存时间为8.3个月。这是第一项描述疑似患有ARVC的英国斗牛犬群体临床特征的研究。需要进一步研究以更好地描述该品种犬这种疾病的临床特征。
