Center for Primary Health Care Research, Lund University/Region Skåne, Lund, Sweden
Group of Molecular Epidemiology & Cancer Precision Prevention, Zhejiang Academy of Medical Sciences, Hangzhou, China.
Diabetes Care. 2018 Apr;41(4):770-774. doi: 10.2337/dc17-0592. Epub 2018 Jan 26.
To explore whether a family history of type 1 diabetes (T1D) is associated with an increased incidence of attention deficit/hyperactivity disorder (ADHD) in offspring.
Individuals with T1D were identified from the nationwide Swedish National Hospital Discharge Register and Swedish Outpatient Register in Sweden and were linked to the Swedish Multi-Generation Register to identify their offspring. Cox regression was used to calculate the hazard ratio (HR) of ADHD in offspring of patients with T1D compared with the general population.
A total of 15,615 individuals were born after their parents were diagnosed with T1D. After a set of confounding factors was controlled for, offspring of T1D patients had a significantly increased risk of ADHD with an HR of 1.29 (95% CI 1.15-1.42). Maternal T1D was associated with an enhanced risk of ADHD (HR 1.35 [95% CI 1.18-1.55]) compared with paternal T1D (HR 1.20 [95% CI 1.03-1.41]), but the difference was not statistically significant.
In this retrospective cohort study, we found that a parental history of T1D was associated with a 29% increased risk of being diagnosed with ADHD. However, the underlying mechanisms need to be explored in future studies.
探讨 1 型糖尿病（T1D）家族史是否与后代注意力缺陷/多动障碍（ADHD）发病率升高有关。
在瑞典，通过全国性的瑞典国家住院登记处和瑞典门诊登记处确定 T1D 患者，并通过瑞典多代登记处确定其子女。采用 Cox 回归计算 T1D 患者子女患 ADHD 的风险比（HR）与普通人群相比。
共有 15615 人在父母被诊断患有 T1D 后出生。在控制了一系列混杂因素后，T1D 患者的子女患 ADHD 的风险显著增加，HR 为 1.29（95%CI 1.15-1.42）。与父系 T1D（HR 1.20 [95%CI 1.03-1.41]）相比，母系 T1D 与 ADHD 风险增加相关（HR 1.35 [95%CI 1.18-1.55]），但差异无统计学意义。
在这项回顾性队列研究中，我们发现父母 T1D 病史与被诊断为 ADHD 的风险增加 29%相关。然而，未来的研究需要探索潜在的机制。
