Barker I, Butchart D G, Gibson J, Lawson J I, Mackenzie N
Br J Anaesth. 1986 Apr;58(4):371-7. doi: 10.1093/bja/58.4.371.
Midazolam and the emulsion formulation of diazepam were compared in a cross-over study in 50 patients undergoing out-patient conservative dentistry, with particular regard to sedation and the quality of recovery. Both agents proved effective, but sedation was achieved more rapidly with midazolam (P = 0.001) and was more effective (P less than 0.02). Significantly greater anterograde amnesia for the dental procedure (P less than 0.001) and a more rapid return to normal activities (P less than 0.02) were found with midazolam. Psychometric testing, however, failed to show any objective differences between the treatments. A mean dose of midazolam 0.14 mg kg-1 was required to achieve sedation equating to 0.29 mg kg-1 of diazepam, although there was considerable variation between individual patients.
在一项交叉研究中，对50名接受门诊保守牙科治疗的患者比较了咪达唑仑和地西泮乳剂配方，特别关注镇静作用和恢复质量。两种药物均证明有效，但咪达唑仑的镇静起效更快（P = 0.001）且效果更好（P < 0.02）。使用咪达唑仑时，对牙科操作的顺行性遗忘明显更严重（P < 0.001），恢复正常活动也更快（P < 0.02）。然而，心理测试未能显示出两种治疗之间的任何客观差异。达到与0.29 mg·kg-1地西泮相当的镇静效果平均需要0.14 mg·kg-1的咪达唑仑，尽管个体患者之间存在相当大的差异。
