Virgilio Edoardo, Giarnieri Enrico, Giovagnoli Maria Rosaria, Montagnini Monica, Proietti Antonella, D'Urso Rosaria, Mercantini Paolo, Balducci Genoveffa, Cavallini Marco
Department of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sapienza University, St. Andrea Hospital, Rome, Italy
Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sapienza University, St. Andrea Hospital, Rome, Italy.
Anticancer Res. 2018 Feb;38(2):613-616. doi: 10.21873/anticanres.12265.
BACKGROUND/AIM: To date, the combination of gastroscopy with biopsy remains the only test validated for screening gastric cancer (GC). Currently, analysis of circulating microRNAs (miRNAs or miRs) is providing interesting information on GC prognosis, but since these molecules are shared by several types of cancer, its clinical use could be questionable and difficult. MicroRNAs in gastric juice (GJ) could represent a cogent alternative to screening GC by biopsy.
We investigated the pertinent literature dealing with GC GJ microRNAs through four popular search engines (PubMed, Science Direct, Scopus and Google Scholar).
As of 2017, only four studies had been published and were all from Chinese experience. MiR-421, miR-129, miR-21, miR-106a and miR-133a were the five molecules studied in the GJ of the enrolled patients.
The GJ miRNA test is reliable and reproducible. The discussed GJ miRNAs appear to be new potential biomarkers for the screening of GC.
背景/目的：迄今为止，胃镜检查与活检相结合仍然是唯一经过验证的胃癌（GC）筛查方法。目前，循环微RNA（miRNA或miR）分析为GC预后提供了有趣的信息，但由于这些分子在多种癌症中都存在，其临床应用可能存在疑问且具有难度。胃液（GJ）中的微RNA可能是替代活检筛查GC的有力选择。
我们通过四个常用搜索引擎（PubMed、Science Direct、Scopus和谷歌学术）对有关GC GJ微RNA的相关文献进行了调查。
截至2017年，仅发表了四项研究，且均来自中国的经验。miR-421、miR-129、miR-21、miR-106a和miR-133a是在所纳入患者的GJ中研究的五个分子。
GJ miRNA检测可靠且可重复。所讨论的GJ miRNAs似乎是筛查GC的新的潜在生物标志物。
