Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong.
Cell Prolif. 2020 Nov;53(11):e12877. doi: 10.1111/cpr.12877. Epub 2020 Oct 6.
Cells utilize different means of inter-cellular communication to function properly. Here, we review the crosstalk between cancer cells and their surrounding environment through microRNA (miRNA)-containing extracellular vesicles (EVs). The current findings suggest that the export of miRNAs and uptake of miRNA-containing EVs might be an active process. As post-transcriptional regulators of gene expression, cancer-derived miRNAs that are taken up by normal cells can change the translational profile of the recipient cell towards a transformed proteome. Stromal cells can also deliver miRNAs via EVs to cancer cells to support tumour growth and cancer progression. Therefore, gaining a better understanding of EV-mediated inter-cellular communication in the tumour microenvironment might lead to the development of novel diagnostic and therapeutic strategies.
细胞利用不同的细胞间通讯方式来正常运作。在这里，我们通过含有 microRNA (miRNA) 的细胞外囊泡 (EV) 来回顾癌细胞与其周围环境之间的串扰。目前的研究结果表明，miRNA 的输出和含有 miRNA 的 EV 的摄取可能是一个主动的过程。作为基因表达的转录后调控因子，被正常细胞摄取的源自癌症的 miRNAs 可以改变受体细胞的翻译谱，使其向转化的蛋白质组转化。基质细胞也可以通过 EV 将 miRNAs 传递给癌细胞，以支持肿瘤生长和癌症进展。因此，更好地理解肿瘤微环境中 EV 介导的细胞间通讯可能会导致新的诊断和治疗策略的发展。
