Department of Neurosciences, Center for Neural Circuits and Behavior, University of California, San Diego, La Jolla, CA, United States.
Department of Biological Sciences, University of California, San Diego, La Jolla, CA, United States.
Front Neural Circuits. 2018 Jan 10;11:112. doi: 10.3389/fncir.2017.00112. eCollection 2017.
Projections from auditory cortex to the amygdala are thought to contribute to the induction of auditory fear learning. In addition, fear conditioning has been found to enhance cortical responses to conditioned tones, suggesting that cortical plasticity contributes to fear learning. However, the functional role of auditory cortex in the retrieval of fear memories is unclear and how fear learning regulates cortical sensory representations is not well understood. To address these questions, we use acute optogenetic silencing and chronic two-photon calcium imaging in mouse auditory cortex during fear learning. Longitudinal imaging of neuronal ensemble activity reveals that discriminative fear learning modulates cortical sensory representations via the suppression of cortical habituation.
听觉皮层向杏仁核的投射被认为有助于听觉恐惧学习的诱导。此外，已经发现恐惧条件反射增强了对条件音调的皮层反应，这表明皮层可塑性有助于恐惧学习。然而，听觉皮层在恐惧记忆检索中的功能作用尚不清楚，恐惧学习如何调节皮层感觉表征也知之甚少。为了解决这些问题，我们在恐惧学习期间使用急性光遗传学沉默和慢性双光子钙成像在小鼠听觉皮层中进行研究。神经元群体活动的纵向成像表明，辨别性恐惧学习通过抑制皮层习惯化来调节皮层感觉表征。
