Clinical Biochemistry and Pharmacology department, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Duke Eye Center, Duke University, Durham, NC, USA.
J Cell Mol Med. 2018 Mar;22(3):2001-2006. doi: 10.1111/jcmm.13479. Epub 2018 Jan 29.
Exosomes are extracellular nanovesicles that mediate a number of cellular processes, including intracellular signalling. There are many published examples of exosome-exosome dimers; however, their relevance has not been explored. Here, we propose that cells release exosomes to physically interact with incoming exosomes, forming dimers that we hypothesize attenuate incoming exosome-mediated signalling. We discuss experiments to test this hypothesis and potential relevance in health and disease.
外泌体是介导多种细胞过程的细胞外纳米囊泡，包括细胞内信号转导。已经有许多关于外泌体-外泌体二聚体的发表案例；然而，它们的相关性尚未得到探索。在这里，我们提出细胞释放外泌体进行物理相互作用，与传入的外泌体形成二聚体，我们假设这种二聚体可以减弱传入的外泌体介导的信号转导。我们讨论了验证这一假设的实验以及在健康和疾病中的潜在相关性。
