Amberntsson Anna, Bärebring Linnea, Winkvist Anna, Lissner Lauren, Brantsæter Anne Lise, Erlund Iris, Papadopoulou Eleni, Augustin Hanna
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
PLoS One. 2025 Feb 25;20(2):e0318071. doi: 10.1371/journal.pone.0318071. eCollection 2025.
Maternal 25-hydroxyvitamin D (25OHD) status has been associated with birth weight and childhood growth. Further, maternal 25OHD status may also influence cardiometabolic outcomes in childhood. This study investigated the association between maternal 25OHD concentration in pregnancy and markers of cardiometabolic risk in 7-12-year-old children.
Data were obtained from the Norwegian Environmental Biobank (NEB) including 244 mother-child pairs in the Norwegian Mother, Father and Child Cohort Study (MoBa) participating in NEB part I and II. Childhood outcomes investigated were z-scores of anthropometrics, blood lipids and hormones. Associations between maternal 25OHD and individual cardiometabolic risk factors in children were assessed by linear regression, adjusted for maternal pre-pregnancy BMI, maternal education, child's sex, age and BMI, and tested for interaction with pre-pregnancy BMI.
Per 10 nmol/L increase in maternal 25OHD, childhood adiponectin z-score increased by 0.067 standard deviations (p = 0.039). There were no associations between maternal 25OHD concentration and any other cardiometabolic risk factor in childhood.
The results indicate that higher maternal vitamin D status during pregnancy may be related to higher childhood adiponectin z-score, but not with any other cardiometabolic risk marker. Whether adiponectin could be one pathway linking vitamin D to cardiometabolic health remains to be determined.
母亲的25-羟基维生素D（25OHD）状态与出生体重和儿童生长有关。此外，母亲的25OHD状态也可能影响儿童期的心脏代谢结局。本研究调查了孕期母亲25OHD浓度与7至12岁儿童心脏代谢风险标志物之间的关联。
数据来自挪威环境生物样本库（NEB），包括参与NEB第一部分和第二部分的挪威母亲、父亲和儿童队列研究（MoBa）中的244对母婴。所调查的儿童期结局包括人体测量学、血脂和激素的z评分。通过线性回归评估母亲25OHD与儿童个体心脏代谢危险因素之间的关联，并对母亲孕前BMI、母亲教育程度、孩子的性别、年龄和BMI进行校正，并测试与孕前BMI的相互作用。
母亲25OHD每增加10 nmol/L，儿童脂联素z评分增加0.067个标准差（p = 0.039）。母亲25OHD浓度与儿童期任何其他心脏代谢危险因素之间均无关联。
结果表明，孕期母亲较高的维生素D状态可能与儿童较高的脂联素z评分有关，但与任何其他心脏代谢风险标志物无关。脂联素是否可能是将维生素D与心脏代谢健康联系起来的一条途径仍有待确定。
