光化学促进的2-酰氧基苯甲醛向2-羟基苯并呋喃酮的极性转换
Photochemically-Enabled Umpolung Conversion of 2-Acyloxybenzaldehydes into 2-Hydroxybenzofuranones.
作者信息
Opryshko Victoria E, Krasnova Svetlana A, Mikhaylov Andrey A, Bogdanova Yulia A, Smirnov Alexander Yu, Baranov Mikhail S, Ivanov Dmitrii S
机构信息
Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Laboratory of Medicinal Substances Chemistry, Institute of Translational Medicine, Pirogov Russian National Research Medical University, Ostrovitianov 1, 117997 Moscow, Russia.
出版信息
Molecules. 2025 Jul 23;30(15):3080. doi: 10.3390/molecules30153080.
2-Acyloxybenzaldehydes are converted into 2-hydroxybenzofuranones in good to excellent yields (60-99%). The reaction proceeds at room temperature in DMSO upon 365 nm LED irradiation under photocatalyst-free conditions. The present atom-economical synthetic approach represents the aldehyde group umpolung reactivity.
2-酰氧基苯甲醛能以良好至优异的产率（60-99%）转化为2-羟基苯并呋喃酮。该反应在无光照催化剂条件下，于室温的二甲基亚砜中，在365纳米发光二极管照射下进行。目前这种原子经济的合成方法体现了醛基的极性翻转反应活性。
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