School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, P.R. China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany Chinese Academy of Sciences, Kunming, P.R. China.
Nat Prod Res. 2020 Aug;34(16):2269-2275. doi: 10.1080/14786419.2018.1531859. Epub 2018 Dec 5.
(+)- and (-)-gancochlearols A () and B (), two pairs of dimeric mertoterpenoid enantiomers were isolated from the fruiting bodies of . Their structures were identified by spectroscopic methods. Biological assessments show that the enantiomers of and are cytotoxic against three human cancer cell lines (A549, K562, Huh-7) and could inhibit COX-2 expression with IC values less than 10 M.
(+)-和(-)-gancochlearols A()和 B()，是从真菌的子实体中分离得到的两对二聚型金缕梅萜烯对映异构体。通过光谱方法鉴定了它们的结构。生物评估表明， 和 的对映异构体对三种人癌细胞系（A549、K562、Huh-7）具有细胞毒性，并且可以抑制 COX-2 的表达，IC 值小于 10μM。
